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FLASH GENE
Symbol CD28 contributors: mct/ - updated : 30-06-2015
HGNC name CD28 molecule
HGNC id 1653
Location 2q33.2      Physical location : 204.571.197 - 204.602.556
Synonym name
  • CD28 antigen (Tp44)
  • T cell antigen CD22
  • cell differentiation antigen CD28 (Tp44), 44kDa, identified by monoclonal antibody 9.3, KOLT2
  • T-cell-specific surface glycoprotein
  • Synonym symbol(s) TP44, MGC138290
    DNA
    TYPE functioning gene
    STRUCTURE 31.36 kb     4 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer
    text structure promoter element CD28GR in exon1 with Sp1/ EGR1binding sites conferring transcriptional activation
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3807 25.1 220 - 1987 2825196
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx    
    Lymphoid/Immunethymus    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • immunoglobulin V type and C type domain
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Cd28
    intraspecies homolog to NADH ubiquinone oxidoreductase
    Homologene
    FAMILY
  • inducible costimulator family (CD28 gene family)
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating PDE7 for T cell activation and required for the formation of the mature immunologic synapse
  • CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of costimulatory signal, with B7-1 (MIC17/CD80) and BF-2 (CD86)
  • homodimer disulfide-linked
  • CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD80, CD86 ligand, PRKCQ (within the immunologic synapse)
  • HNRNPLL expression is dependent on CD28 signaling, providing a mechanism by which CD28 can regulate splicing in T cells and insight into how HNRNPLL can influence signal-induced alternative splicing in T cells
  • enforces a requirement for CD28 costimulation by limiting IL2 production
  • cell & other
    REGULATION
    Other regulated by CBLB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to celiac disease
  • to unexplained pregnancy loss
  • Variant & Polymorphism other imbalance in CTLA4/CD28 expression or suppressed T-cell activity at the maternal-fetal interface may confer susceptibility to unexplained pregnancy loss
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS