Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

CD24

contributors: mct/pgu - updated : 11-07-2022

HGNC name	CD24 molecule
HGNC id	1645

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q21      Physical location : 21.152.525 - 21.154.705
Synonym name	CD24 antigen
	cell differentiation antigen CD24, glycosyl phosphatidylinositol (GPI) linked membrane sialoglycoprotein, identified by monoclonal antibodies BA-1, VIB-E3, B
	CD24 antigen (small cell lung carcinoma cluster 4 antigen)
Synonym symbol(s)	CD24A, FLJ22950, FLJ43543, MGC75043

DNA

TYPE	functioning gene
STRUCTURE	7.02 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see LAMA4

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013230 2 - 2194 NP_037362 5.3 80 - 2022 35048182 NM_001291738 3 - 2295 NP_001278667 - 80 - 2022 35048182 NM_001291737 3 - 2440 NP_001278666 - 80 - 2022 35048182 NM_001359084 2 - 2156 NP_001346013 - 80 - 2022 35048182 NM_001291739 2 - 2374 NP_001278668 - 129 - 2022 35048182

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine thyroid       highly Nervous brain       moderately Reproductive male system prostate     moderately Respiratory respiratory tract trachea     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Lymphoid/Immune B cell Lymphoid/Immune lymphocyte Muscular myocyte Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	myofiber synaptic nuclei
	overexpressed in normal human fetal kidneys (8 to 38 weeks of gestation)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Cd24a
	homolog to Drosophila CG8258
	homolog to C.elegans Y55F3AR.3

intraspecies	homolog to CD24L1
	homolog to CD24L2
	homolog to CD24L3
	homolog to CD24L4

Homologene

FAMILY

CD24 family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	glycosyl phosphatidylinositol (GPI)-anchor

basic FUNCTION	differentiating and activating granulocytes and B lymphocytes
	playing a role of ligand for P-selectin (SELP) on tumor cells
	having a role in presynaptic differentiation, and required for normal presynaptic maturation and function
	involved in cell adhesion, invasion, and metastasis, in tumorigenesis
	glycosylphosphatidylinositol (GPI) anchor protein as a cell surface marker for nucleus pulposus
	augmenting beta1-dependent cell motility and stimulating transmigration and invasion across a monolayer of endothelial cells
	in association with SIGLEC10, negatively regulates stimulatory activity of HSP70, HSP90 and inhibits NF-KappaB activation
	protects the host against a lethal response to pathological cell death and discriminiates danger-versus pathogen associated molecular patterns
	important marker of malignancy and poor prognosis in various cancers, and may promote cancer development and progression in the breast, ovary and urinary bladder
	cell-surface sialoglycoprotein expressed on immature cells that disappears after they have reached their final stage of differentiation
	having a cell-specific expression in the developing human kidney and its dysregulation during fetal urinary tract obstruction
	role of NFAT5 and CD24 in the homeostasis of T cells under osmostress
	inhibits the specific endoribonuclease activity of G3BP1 toward ARL2BP mRNA in stress granules)
	surface CD24 may play a role in the inhibition of cell invasion and metastasis, and intracellular CD24 inhibits invasiveness and metastasis through its influence on the posttranscriptional regulation of ARL2BP mRNA levels via G3BP1 RNase activity
	necessary for subsequent development of lung metastases in bladder carcinoma
	role of CD24 in the delayed/defective cell death in sepsis
	CD24 serves as a costimulatory factor of T cells that regulate their homeostasis and proliferation, while in B cells, CD24 is functionally involved in cell activation and differentiation
	presence of the CD24-SIGLEC10 in the regions of fetal-maternal interactions suggests a possible role in mediating immune tolerance at the fetal-maternal interface
	is a AR-dependent gene that its expression can be induced by androgen and suppressed by antiandrogen treatment
	is required for regulating gene expression, but not glucose uptake, during adipogenesis
	CD24 is a highly expressed, anti-phagocytic signal in several cancers
	mucin-like glycoprotein expressed at the surface of hematopoietic and tumor cells and recently shown to be expressed in the first trimester placenta

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

immunity/defense

text	humoral defense mechanism

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to a lectin-like ligand (on CD24 carbohydrates)
	recruiting beta1 integrin into lipid raft domains
	NFAT5 target induced by hypertonicity, and required to sustain T cell expansion under osmostress (NFAT5 bound to the CD24 promoter in response to hypertonicity facilitated the local derepression of chromatin and enhanced the expression of CD24 mRNA and protein)
	CD24 in stress granules is associated with G3BP1, a phosphorylation-dependent endoribonuclease
	interacting with NDRG2 (NDRG2 exerted its anti-tumor activity by regulating CD24, a molecule that mediates cell-cell interaction, tumor proliferation and adhesion)
	role for tumour-expressed CD24 in promoting immune evasion through its interaction with SIGLEC10, which is expressed by tumour-associated macrophages
	ELF5 inhibits likely migration and invasion of breast cancer cells by regulating CD24 expression

cell & other

REGULATION

Other	loss of expression during differentiation of primary B-cells to antibody-forming cells
	modulated by IGFBP2 and contributes to IGFBP2-enhanced invasiveness of glioblastoma multiforme cells

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non small cell lung cancer is associated with adenocarcinoma histology and disease progression and cancer-related death, indicative of aggressive tumor behavior tumoral     --low   in squamous cell carcinoma of the head and neck tumoral     --over   in chordoma, a malignant primary tumor derived from notochordal cells tumoral     --over   in the herniated nucleus pulposus tumoral         expression of CD24 correlates with poor prognosis in a variety of carcinomas constitutional     --low   in preterm Preeclampsia cases, and could be linked to reduced immune tolerance in preeclampsia tumoral     --over   is more common in breast cancer than in corresponding normal tissue

Susceptibility

to multiple sclerosis (genetic modifier for susceptibility and progression) to systemic lupus erythematosus (SLE)

Variant & Polymorphism	A57V allele
	CD24 Ala57Val polymorphism may predispose to SLE incidence and can be linked to immunologic manifestations and production of autoantibodies in this disease

Candidate gene
Marker	is a promising biomarker for autoimmune diseases
Therapy target
	System Type Disorder Pubmed cancer urinary   promising therapeutic target for antimetastatic therapy in bladder carcinoma cancer digestive liver identification of the TWIST2-CD24 signaling pathway provides a potential therapeutic approach to target cancer stem cells in HCCs cancer     therapeutic potential for CD24 blockade in cancer immunotherapy cancer     treatment strategy of tumors through targeting CD24 on the surface of tumor cells or SIGLEC10 on immune cells immunology autoimmune   novel therapeutic target for autoimmune diseases cancer digestive liver CD24-SIGLEC10 interaction, may represent a therapeutic target in HCC patients

ANIMAL & CELL MODELS