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FLASH GENE
Symbol CD24 contributors: mct/pgu - updated : 04-10-2011
HGNC name CD24 molecule
HGNC id 1645
Location 6q11.22      Physical location : 21.152.525 - 21.154.705
Synonym name
  • CD24 antigen
  • cell differentiation antigen CD24, glycosyl phosphatidylinositol (GPI) linked membrane sialoglycoprotein, identified by monoclonal antibodies BA-1, VIB-E3, B
  • CD24 antigen (small cell lung carcinoma cluster 4 antigen)
    • Synonym symbol(s) CD24A, FLJ22950, FLJ43543, MGC75043
    DNA
    TYPE functioning gene
    STRUCTURE 4.76 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see LAMA4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2194 5.3 80 - 1995 7553654
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinethyroid   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Lymphoid/ImmuneB cell
    Lymphoid/Immunelymphocyte
    Muscularmyocyte
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text
  • myofiber synaptic nuclei
  • overexpressed in normal human fetal kidneys (8 to 38 weeks of gestation)
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cd24a
    homolog to Drosophila CG8258
    homolog to C.elegans Y55F3AR.3
    intraspecies homolog to CD24L1
    homolog to CD24L2
    homolog to CD24L3
    homolog to CD24L4
    Homologene
    FAMILY
  • CD24 family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text glycosyl phosphatidylinositol (GPI)-anchor
    basic FUNCTION
  • differentiating and activating granulocytes and B lymphocytes
  • playing a role of ligand for P-selectin (SELP) on tumor cells
  • having a role in presynaptic differentiation, and required for normal presynaptic maturation and function
  • involved in cell adhesion, invasion, and metastasis, in tumorigenesis
  • glycosylphosphatidylinositol (GPI) anchor protein as a cell surface marker for nucleus pulposus
  • augmenting beta1-dependent cell motility and stimulating transmigration and invasion across a monolayer of endothelial cells
  • in association with SIGLEC10, negatively regulates stimulatory activity of HSP70, HSP90 and inhibits NF-KappaB activation
  • protects the host against a lethal response to pathological cell death and discriminiates danger-versus pathogen associated molecular patterns
  • important marker of malignancy and poor prognosis in various cancers, and may promote cancer development and progression in the breast, ovary and urinary bladder
  • cell-surface sialoglycoprotein expressed on immature cells that disappears after they have reached their final stage of differentiation
  • having a cell-specific expression in the developing human kidney and its dysregulation during fetal urinary tract obstruction
  • role of NFAT5 and CD24 in the homeostasis of T cells under osmostress
  • inhibits the specific endoribonuclease activity of G3BP1 toward ARL2BP mRNA in stress granules)
  • surface CD24 may play a role in the inhibition of cell invasion and metastasis, and intracellular CD24 inhibits invasiveness and metastasis through its influence on the posttranscriptional regulation of ARL2BP mRNA levels via G3BP1 RNase activity
  • necessary for subsequent development of lung metastases in bladder carcinoma
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS immunity/defense
    text humoral defense mechanism
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to a lectin-like ligand (on CD24 carbohydrates)
  • recruiting beta1 integrin into lipid raft domains
  • NFAT5 target induced by hypertonicity, and required to sustain T cell expansion under osmostress (NFAT5 bound to the CD24 promoter in response to hypertonicity facilitated the local derepression of chromatin and enhanced the expression of CD24 mRNA and protein)
  • CD24 in stress granules is associated with G3BP1, a phosphorylation-dependent endoribonuclease
  • interacting with NDRG2 (NDRG2 exerted its anti-tumor activity by regulating CD24, a molecule that mediates cell-cell interaction, tumor proliferation and adhesion)
    • cell & other
    REGULATION
    Other loss of expression during differentiation of primary B-cells to antibody-forming cells
    modulated by IGFBP2 and contributes to IGFBP2-enhanced invasiveness of glioblastoma multiforme cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non small cell lung cancer is associated with adenocarcinoma histology and disease progression and cancer-related death, indicative of aggressive tumor behavior
    tumoral     --low  
    in squamous cell carcinoma of the head and neck
    tumoral     --over  
    in chordoma, a malignant primary tumor derived from notochordal cells
    tumoral     --over  
    in the herniated nucleus pulposus
    tumoral        
    expression of CD24 correlates with poor prognosis in a variety of carcinomas
    Susceptibility
  • to multiple sclerosis (genetic modifier for susceptibility and progression)
  • to systemic lupus erythematosus (SLE)
    • Variant & Polymorphism
  • A57V allele
  • CD24 Ala57Val polymorphism may predispose to SLE incidence and can be linked to immunologic manifestations and production of autoantibodies in this disease
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    promising therapeutic target for antimetastatic therapy in bladder carcinoma
    cancerdigestiveliver
    identification of the TWIST2-CD24 signaling pathway provides a potential therapeutic approach to target cancer stem cells in HCCs
    ANIMAL & CELL MODELS