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FLASH GENE
Symbol CD209 contributors: mct/npt - updated : 13-03-2009
HGNC name CD209 molecule
HGNC id 1641
Location 19p13.2      Physical location : 7.804.880 - 7.812.464
Synonym name
  • dendritic cell-specific ICAM3-grabbing non-integrin
  • C-type lectin domain family 4, member L
  • HIV GP120 binding protein
  • CD209 antigen
  • Synonym symbol(s) DC-SIGN1, CDSIGN, CLEC4, DC-SIGN, MGC129965, CLEC4L
    DNA
    TYPE functioning gene
    STRUCTURE 7.52 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • transcriptional start site and Ap1, Sp1, ETS1 and NFKB binding sites
  • promoter variant DCSIGN1-336
  • four major transcriptional start sites at +1, +271, +364, and +435, with the +364 site being the most abundantly expressed in dendritic cells
  • AP-1, Sp1, Ets-1, and NF-kappaB binding sites
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3920 30.3 268 - Geijtenbeek (2000)
    - splicing 4196 41 360 - Geijtenbeek (2000)
    - splicing 4052 35 312 - Geijtenbeek (2000)
    - splicing 4256 43.2 380 - Geijtenbeek (2000)
    - splicing 4310 45 398 - Geijtenbeek (2000)
    - splicing 3845 27.2 243 - Geijtenbeek (2000)
    - splicing 4328 45.6 404 - Geijtenbeek (2000)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Epithelialbarrier/liningendometrium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal cytoplasmic hydrophobic region
  • a SET of tandem repeats (seven complete and one incomplete)
  • a neck region, with up of seven repeats of 23 amino acids each, known to play a major role in the pathogen-binding properties of these proteins
  • an extra-cellular domain consisting of an extended neck region encoded by tandem repeats that support the carbohydrate-recognition domain, which plays a crucial role in influencing the pathogen-binding properties of this antigen (Khoo 2008)
  • C terminal homolog to C-type lectin
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediates transient adhesion with T cells (Geijtenbeek 2000)
  • enables T cell receptor engagement by stabilization of the DC-T cell contact zone (Geijtenbeek 2000)
  • cell surface receptor binding to oligosaccharide ligands found on human tissues as well as on pathogens including viruses, bacteria, and parasites (Feinberg 2005)
  • attachment receptor of dengue virus, mediating transient adhesion of dendritic cells with T cells
  • playing a crucial role in dengue pathogenesis, discriminating between severe dengue fever and dengue hemorrhagic fever
  • recognize a plethora of pathogens, including bacteria, viruses, and parasites
  • playing a role through the Ca2+ binding site in the phagocytosis of E. coli (Iyori 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds ICAM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to dengue fever, severe form
  • to pulmonary tuberculosis
  • Variant & Polymorphism other
  • allele G of variant DCSIGN1-336 was associated with strong protection against dengue fever
  • polymorphisms increasing the risk of pulmonary tuberculosis in addition with PTX3
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyimmunodeficiency 
    an effective microbicide should target both syndecan-3 and CD209 on dendritic cells to prevent HIV transmission
    ANIMAL & CELL MODELS