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FLASH GENE
Symbol CD200R1 contributors: mct - updated : 01-02-2012
HGNC name CD200 receptor 1
HGNC id 24235
Location 3q13.2      Physical location : 112.641.531 - 112.693.937
Synonym name
  • MOX2 receptor
  • cell surface glycoprotein OX2 receptor
  • cell surface glycoprotein receptor CD200
  • Synonym symbol(s) OX2R, MOX2R, CD200R, HCRTR2
    DNA
    TYPE functioning gene
    STRUCTURE 52.41 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2272 - 348 - 2003 12853143
    4 - 1025 - 188 - 2003 12853143
    four exons, a frameshift resulting in an early stop codon, loss of an Ig and transmembrane domains
    3 - 956 - 165 - 2003 12853143
    three exons, a frameshift, an early stop codon and loss of Ig and transmembrane domains
    7 splicing 2203 36 325 - 2003 12853143
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils     Homo sapiens
    Nervousbrain     Homo sapiens
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    Lymphoid/ImmuneT cell
    Nervousglia Homo sapiens
    Skeletonosteoclast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig-like domains
  • a single transmembrane domain
  • eight N-glycosylation sites
  • two IgSF domains
  • intracellular domain that mediates downstream signaling, typically delivering an inhibitory signal
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • CD200R family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • the interaction receptor-substrate may function as a myeloid down-regulatory signal
  • with CD200, having a role in regulating bone formation
  • CD200-CD200R1 pathway seems of critical relevance for macrophage-mediated damage in autoimmune inflammation of the CNS
  • suppresses immune activity via its ligand CD200 (CD200-CD200R1 interactions have recently been considered to contribute to the "immune privileged" status of the central nervous system)
  • CD200R1/CD200 pathway is up-regulated in arthritis and plays a significant physiological role in regulating the severity of disease
  • CD200-CD200R couple could be a new target to control bone diseases
  • CD200-CD200R1 interaction is involved in the anti-inflammatory and neuroprotective action of PPARG agonists
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CD200 (CD200-CD200R axis is therefore a putative regulator of bone mass, via the formation of osteoclasts)
  • interaction between CD200, and CD200R1, is one of the mechanisms involved in keeping the microglial proinflammatory phenotype under control in physiological conditions
  • cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    eight N-glycosylation sites
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    enhanced expression of CD200 and CD200R1 in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy
    constitutional     --other  
    aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene it is very promising to regulate microglia activation in Parkinson disease via targeting CD200-CD200R1 signaling pathways
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    it is very promising to regulate microglia activation in Parkinson disease via targeting CD200-CD200R1 signaling pathways
    cancerskin 
    CD200 and CD200R1 are potential therapeutic target for metastatic melanoma
    ANIMAL & CELL MODELS