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FLASH GENE
Symbol CD2 contributors: npt/mct - updated : 01-07-2009
HGNC name CD2 molecule
HGNC id 1639
Location 1p13.1      Physical location : 117.297.085 - 117.311.850
Synonym name
  • cell differentiation antigen CD2 (p50), identified by monoclonal antibodies 9.6, T11, 35.1,M-T910
  • CD2 antigen (p50), sheep red blood cell receptor
  • CD2 antigen
  • LFA-3 receptor
  • Rosette receptor
  • T-cell surface antigen T11/Leu-5
  • lymphocyte-function antigen-2
  • Synonym symbol(s) LEU5, T11, SRBC, LFA-2, FLJ46032
    DNA
    TYPE functioning gene
    STRUCTURE 14.77 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure a 3' locus control region LCR-CD2
    MAPPING cloned Y linked N status confirmed
    Physical map
    AMPD1 1p13 adenosine monophosphate deaminase 1 (isoform M) NRAS 1p13.2 neuroblastoma RAS viral (v-ras) oncogene homolog D1S155E 1p22 NRAS-related gene FLJ21168 1p13.1 hypothetical protein FLJ21168 SYCP1 1p13 synaptonemal complex protein 1 TSHB 1p13 thyroid stimulating hormone, beta TSPAN-2 1p13.1 tetraspan 2 NGFB 1p13.1 nerve growth factor, beta polypeptide LOC391068 1 similar to mCAF1 protein VANGL1 1p11-p13.1 vang-like 1 (van gogh, Drosophila) LOC387624 1 hypothetical gene supported by NM_024062 CASQ2 1p13.3-p11 calsequestrin 2 (cardiac muscle) NHLH2 1p12-p11 nescient helix loop helix 2 LOC343019 1p12 similar to Hnrpa1 protein SLC22A15 1p12 solute carrier family 22 (organic cation transporter), member 15 FLJ38716 1p12 hypothetical protein FLJ38716 ATP1A1 1p13 ATPase, Na+/K+ transporting, alpha 1 polypeptide MGC16179 1p12 hypothetical protein MGC16179 LOC148766 1p12 hypothetical LOC148766 CD58 1p13 CD58 antigen, (lymphocyte function-associated antigen 3) IGSF3 1p13 immunoglobulin superfamily, member 3 LOC388667 1 LOC388667 LOC391069 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC339396 1p12 similar to neurofilament, heavy polypeptide 200kDa; Neurofilament, heavy polypeptide; neurofilament, heavy polypeptide (200kD) CD2 1p13.1 CD2 antigen (p50), sheep red blood cell receptor PTGFRN 1p13.1-q21.3 prostaglandin F2 receptor negative regulator IGSF2 1p13 immunoglobulin superfamily, member 2 TTF2 1p13.1 transcription termination factor, RNA polymerase II TRIM45 1q12-21 tripartite motif-containing 45 LOC391070 1 similar to 40S ribosomal protein S15a B7-H4 1p12 immune costimulatory protein B7-H4 MAN1A2 1p13.1 mannosidase, alpha, class 1A, member 2 FLJ20202 1p12 FLJ20202 protein LOC391071 1 similar to voltage-dependent anion channel 2 GDAP2 1q21.1 ganglioside induced differentiation associated protein 2 WDR3 1p13-p12 WD repeat domain 3 LOC391072 1 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC343492 1p12 similar to Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1595 39.3 351 - De Jager (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/HematopoieticNK cell
    Blood/Hematopoieticthymocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus extracellular segment
  • two immunoglobulin superfamily domains
  • cytoplasmic tail containing no protein kinase as well as no phosphatase domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd2
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in antigen recognition via its role in adhesion and signal transduction
  • complex CD2/CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes (Li 2008)
  • receptor on T lymphocytes essential for T cell adhesion and stimulation by antigen presenting cells (APCs) (Zhu 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CD58 prior antigen recognition by TCR (CD58 receptor)
  • SRBC receptor
  • LFA3 receptor
  • interacting with an adaptor protein (CDC2BP) to trigger cell adhesion
  • interaction with CD58 (interaction mediating tight adhesion within the 2D cell-cell interface) (Zhu 2006)
  • with CD58 up-regulate the expression of transcription factor FOXP3P3 leading to the enhanced function of CD4(+)CD25(high) regulatory T cells that are defective in subjects with MS (De Jager 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection (Li 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS