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FLASH GENE
Symbol CD1E contributors: SGE/pgu - updated : 27-07-2011
HGNC name CD1e molecule
HGNC id 1638
Location 1q23.1      Physical location : 158.323.485 - 158.327.341
Synonym name
  • cell differentiation antigen CD1E (see CD1@)
  • CD1E antigen, e polypeptide
  • thymocyte antigen CD1E
  • T-cell surface glycoprotein CD1e
  • differentiation antigen CD1-alpha-3
  • leukocyte differentiation antigen
  • Synonym symbol(s) RP11-101J8.5, HSCDIEL, CD1A, R2, FLJ17609
    DNA
    TYPE functioning gene
    STRUCTURE 3.80 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FCRH1 1q21-q22 Fc receptor-like protein 1 CD5L 1q21-q23 CD5 antigen-like (scavenger receptor cysteine rich family) MRPS21P2 1q22 mitochondrial ribosomal protein S21 pseudogene 2 LOC284623 1q23.1 hypothetical LOC284623 KIRREL 1q21-q25 kin of IRRE like (Drosophila) LOC284674 1q23.1 similar to RNA polymerase II elongation factor ELL2 CD1D 1q22-q23 CD1D antigen, d polypeptide CD1A 1q22-q23 CD1A antigen, a polypeptide CD1C 1q22-q23 CD1C antigen, c polypeptide CD1B 1q22-q23 CD1B antigen, b polypeptide CD1E 1q22-q23 CD1E antigen, e polypeptide LOC128360 1q23.1 similar to Olfactory receptor 10T2 LOC391107 1 similar to Olfactory receptor 10K1 OR10T1P 1q25.3 olfactory receptor, family 10, subfamily T, member 1 pseudogene LOC391109 1 similar to Olfactory receptor 10K1 LOC343406 1q23.1 similar to Olfactory receptor 10R2 LOC391110 1 similar to seven transmembrane helix receptor OR10R1P 1q25.3 olfactory receptor, family 10, subfamily R, member 1 pseudogene LOC391111 1 similar to Heat shock protein HSP 90-alpha (HSP 86) LOC391112 1 similar to Olfactory receptor 6Y1 LOC128366 1q23.1 similar to Olfactory receptor 6P1 LOC128367 1q23.1 similar to seven transmembrane helix receptor LOC128368 1q23.1 similar to Olfactory receptor 10Z1 SPTA1 1q21 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) LOC391113 1 similar to Olfactory receptor 6K2 LOC391114 1 similar to Olfactory receptor 6K3 LOC128370 1q23.1 similar to seven transmembrane helix receptor LOC391115 1 similar to olfactory receptor GA_x6K02T2P20D-21063569-21062619 LOC128371 1q23.1 similar to Olfactory receptor 6K6 LOC128372 1q23.1 similar to Olfactory receptor 6N1 LOC391116 1 similar to Olfactory receptor 6N2 MNDA 1q22 myeloid cell nuclear differentiation antigen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2063 - 388 - -
    also called variant 1/isoform a
    - - 1385 - 144 - -
    also called variant 11/isoform k
    - - 1820 - 289 - -
    also called variant 13/isoform m
    - - 1646 - 231 - -
    also called variant 9 (or 7)/isoform i
    - - 1550 - 199 - -
    also called variant 10/isoform j
    - - 1349 - 132 - -
    also called variant 12/isoform i
    4 - 1514 - 187 - -
    also called variant 9/isoform e
    4 - 1446 - 101 - -
    also called variant 10/isoform f
    6 - 1916 - 321 - -
    also called variant 4/isoform d
    6 - 2013 - 290 - -
    also called variant 3/isoform c
    6 - 2081 - 376 - -
    also called variant 2/isoform b
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunethymus   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Ig-like (immunoglobulin-like) domain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor proteolytically cleaved in late endosomes to yield a soluble form
    HOMOLOGY
    Homologene
    FAMILY
  • CD1 family of major histocompatibility (MHC)
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • cleaved into a soluble form found in lysosome lumen
  • LAPTM5 and CD1E colocalize in trans-Golgi and late endosomal compartments
  • basic FUNCTION
  • involved in the immune response
  • helping to expand the repertoire of glycolipidic T cell antigens to optimize antimicrobial immune resposnes
  • related to the peptide-presenting MHC class I family
  • could be a pot
  • participates in the presentation of lipid antigens in dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterodimer with beta-2-microglobulin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of LAPTM5 with CD1E, suggesting that LAPTM5 might influence the role of CD1E in the presentation of lipid antigens
  • cell & other
    REGULATION
    Other mono-ubiquitinated, ubiquitination of CD1E appears to trigger its exit from Golgi compartments and its transport to endosomes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other one variant of CD1E with a proline at position 194, does not assist PIM(6) presentation to CD1b-restricted specific T cells, homozygous individuals might display an altered immune response to complex glycolipid Ags
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS