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FLASH GENE
Symbol CD1D contributors: mct/npt - updated : 27-05-2014
HGNC name CD1d molecule
HGNC id 1637
Location 1q23.1      Physical location : 158.149.736 - 158.156.214
Synonym name
  • thymocyte antigen CD1D
  • cell differentiation antigen CD1D, identified by monoclonal antibody NOR3, (see CD1@)
  • HMC class I antigen-like glycoprotein CD1D
  • CD1D antigen, d polypeptide
  • T-cell surface glycoprotein CD1d
  • Synonym symbol(s) CD1A, MGC34622, R3, R3G1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 6.48 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • at least six exons
  • TATA boxless dual promoters with multiple transcription initiation sites and SP1 playing a crucial role in the function of the proximal promoter
  • MAPPING cloned Y linked N status provisional
    Physical map
    IRTA2 1q21 similar to Olfactory receptor 6K6 IRTA1 1q21 similar to Olfactory receptor 6K6 LOC391105 1 similar to dJ801G22.2 (novel protein similar to immunoglobulin gamma FC receptor 1 (FGCR1)) FCRH3 1q21-q22 Fc receptor-like protein 3 LOC148300 1q23.1 son-pseudogene LOC391106 1 similar to voltage-dependent anion channel 1 SPAP1 1q21 SH2 domain containing phosphatase anchor protein 1 FCRH1 1q21-q22 Fc receptor-like protein 1 CD5L 1q21-q23 CD5 antigen-like (scavenger receptor cysteine rich family) MRPS21P2 1q22 mitochondrial ribosomal protein S21 pseudogene 2 LOC284623 1q23.1 hypothetical LOC284623 KIRREL 1q21-q25 kin of IRRE like (Drosophila) LOC284674 1q23.1 similar to RNA polymerase II elongation factor ELL2 CD1D 1q22-q23 CD1D antigen, d polypeptide CD1A 1q22-q23 CD1A antigen, a polypeptide CD1C 1q22-q23 CD1C antigen, c polypeptide CD1B 1q22-q23 CD1B antigen, b polypeptide CD1E 1q22-q23 CD1E antigen, e polypeptide LOC128360 1q23.1 similar to Olfactory receptor 10T2 LOC391107 1 similar to Olfactory receptor 10K1 OR10T1P 1q25.3 olfactory receptor, family 10, subfamily T, member 1 pseudogene LOC391109 1 similar to Olfactory receptor 10K1 LOC343406 1q23.1 similar to Olfactory receptor 10R2 LOC391110 1 similar to seven transmembrane helix receptor OR10R1P 1q25.3 olfactory receptor, family 10, subfamily R, member 1 pseudogene LOC391111 1 similar to Heat shock protein HSP 90-alpha (HSP 86) LOC391112 1 similar to Olfactory receptor 6Y1 LOC128366 1q23.1 similar to Olfactory receptor 6P1 LOC128367 1q23.1 similar to seven transmembrane helix receptor LOC128368 1q23.1 similar to Olfactory receptor 10Z1 SPTA1 1q21 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) LOC391113 1 similar to Olfactory receptor 6K2 LOC391114 1 similar to Olfactory receptor 6K3 LOC128370 1q23.1 similar to seven transmembrane helix receptor LOC391115 1 similar to olfactory receptor GA_x6K02T2P20D-21063569-21062619 LOC128371 1q23.1 similar to Olfactory receptor 6K6
    RNA
    TRANSCRIPTS type messenger
    text eight alternative transcripts (PMID: 11006091)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3795 49 335 - 2000 11006091
    in frame
    - - - - - - 2000 11006091
    out of frame lacking the B2M binding domain
    - - - - - - 2000 11006091
    out of frame, antigen and B2M binding sites partially defective
    - - - - - - 2000 11006091
    in frame
    - - - - - - 2000 11006091
    out of frame, antigen and B2M binding sites partially defective
    - - - - - - 2000 11006091
    out of frame, antigen and B2M binding sites partially defective
    - - - - - - 2000 11006091
    - - - - - - 2000 11006091
    out of frame, antigen and B2M binding sites partially defective
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Lymphoid/Immunelymph node    
     spleen    
    Reproductivefemale systemuteruscervix  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period growth/childhood
    Text strong in the skin of the children and declined gradually with age, being moderate in adults and weak in the elderly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three external domains : the antigen binding alpha 1 (domain 1) and the beta(2) microglobulain binding sites (alpha 2 and 3 domains)
  • a transmembrane segment (TM1)
  • a short cytoplasmic tail, with a tyrosine-based endosomal targeting motif (YXXZ), and a signal that may have relevance to other type I integral membrane proteins that traverse through the endocytic pathway
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd1d
    intraspecies homolog to CD1A,CD1B,CD1C
    Homologene
    FAMILY
  • immunoglobulin C-type family
  • CATEGORY immunity/defense , antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • translocated in the ER
  • CD1D molecules are constantly internalized from the cell surface, recycled through the endocytic compartments, and re-expressed on the cell surface
  • basic FUNCTION
  • presentation of lipid antigens to natural killer (NK) T cells
  • ligand for CD8(+) T cells
  • nonclassical Ag-presenting molecule that presents glycolipid Ags to NKT cells that are involved in immune defense and tumor rejection
  • also plays a role in immunoregulatory functions in the epidermis
  • present lipids to a unique subpopulation of T cells called NKT cells
  • MHC class I-like molecule comprised of a transmembrane glycoprotein (heavy chain) associated with beta2-microglobulin (B2m) that presents lipid antigens to NKT cells
  • can undergo multiple rounds of recycling between the cell surface and endosomal compartments to extensively survey changes in lipid composition
  • related to the peptide-presenting MHC class I family
  • could be a pot
  • CD1A, CD1B, CD1C, CD1D bind and present lipid-based antigens to T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of membrane glycoprotein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to B2M
  • associating in the ER with both CANX, CALR and with GRP58 in a manner dependent on glucose trimming of its N-linked glycans
  • is a CD1D receptor that inhibits CD1D-mediated immune responses (interaction between LILRB12 and CD1D may provide new insights into the regulation of NKT-mediated immunity)
  • C/EBP-beta binds to the CCAAT box in the CD1D promoter
  • after translocation into the ER, newly synthesized CD1D heavy chains are rapidly glycosylated and bind CALR and calnexin (CNX), which recognize monoglucosylated N-linked glycans
  • ROCK1 and ROCK2, negatively regulate CD1D-mediated Ag presentation
  • binds to CD1D and inhibits its recognition by NKT cells
  • up-regulation of CD1C enhances NKT recognition of CD1D and down-regulation reduces CD1D recognition
  • BCL2L1 regulates CD1D-mediated Ag processing and presentation to NKT cells by altering the late endosomal compartment and changing the intracellular localization of CD1D
  • cell & other
  • binding to CD8 (+) T cells
  • bind a surprising diversity of lipid structures within the secretory pathway, including compounds that have been reported to play roles in cancer, autoimmune diseases, lipid signaling, and cell death
  • both CD1D and CD1C are upregulated by RARA signaling in human B cells which is distinct from effects reported in dendritic cells, in which CD1C is inversely downregulated
  • REGULATION
    Other regulated by MTP in the endoplasmic reticulum
    regulated by IFN-gamma, NF-IL-6, and T cell factor 1/lymphoid enhancer-binding factor 1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    is associated with CD86 over-expression in B cells from systemic lupus erythematosus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    exciting new target for immunotherapy of cancer based on tumor immunoregulation
    ANIMAL & CELL MODELS