Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD1C contributors: mct - updated : 07-04-2014
HGNC name CD1c molecule
HGNC id 1636
Location 1q23.1      Physical location : 158.259.562 - 158.264.563
Synonym name
  • cell differentiation antigen CD1C,identified by monoclonal antibodies L161,7C6,PHM3 (see CD1@)
  • CD1C antigen, c polypeptide
  • cortical thymocyte antigen CD1C
  • differentiation antigen CD1-alpha-3
  • T-cell surface glycoprotein CD1c
  • Synonym symbol(s) CD1, BDCA1, R7, CD1A
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FCRH3 1q21-q22 Fc receptor-like protein 3 LOC148300 1q23.1 son-pseudogene LOC391106 1 similar to voltage-dependent anion channel 1 SPAP1 1q21 SH2 domain containing phosphatase anchor protein 1 FCRH1 1q21-q22 Fc receptor-like protein 1 CD5L 1q21-q23 CD5 antigen-like (scavenger receptor cysteine rich family) MRPS21P2 1q22 mitochondrial ribosomal protein S21 pseudogene 2 LOC284623 1q23.1 hypothetical LOC284623 KIRREL 1q21-q25 kin of IRRE like (Drosophila) LOC284674 1q23.1 similar to RNA polymerase II elongation factor ELL2 CD1D 1q22-q23 CD1D antigen, d polypeptide CD1A 1q22-q23 CD1A antigen, a polypeptide CD1C 1q22-q23 CD1C antigen, c polypeptide CD1B 1q22-q23 CD1B antigen, b polypeptide CD1E 1q22-q23 CD1E antigen, e polypeptide LOC128360 1q23.1 similar to Olfactory receptor 10T2 LOC391107 1 similar to Olfactory receptor 10K1 OR10T1P 1q25.3 olfactory receptor, family 10, subfamily T, member 1 pseudogene LOC391109 1 similar to Olfactory receptor 10K1 LOC343406 1q23.1 similar to Olfactory receptor 10R2 LOC391110 1 similar to seven transmembrane helix receptor OR10R1P 1q25.3 olfactory receptor, family 10, subfamily R, member 1 pseudogene LOC391111 1 similar to Heat shock protein HSP 90-alpha (HSP 86) LOC391112 1 similar to Olfactory receptor 6Y1 LOC128366 1q23.1 similar to Olfactory receptor 6P1 LOC128367 1q23.1 similar to seven transmembrane helix receptor LOC128368 1q23.1 similar to Olfactory receptor 10Z1 SPTA1 1q21 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) LOC391113 1 similar to Olfactory receptor 6K2 LOC391114 1 similar to Olfactory receptor 6K3 LOC128370 1q23.1 similar to seven transmembrane helix receptor LOC391115 1 similar to olfactory receptor GA_x6K02T2P20D-21063569-21062619 LOC128371 1q23.1 similar to Olfactory receptor 6K6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2592 - 333 - Martin (1997)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one Ig-like (immunoglobulin-like) domain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • major histocompatibility (MHC) family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • could promote dendritic cell maturation in the presence of LPS and IFNG (Vincent 2002)
  • antigen-presenting protein that binds self and non-self lipid and glycolipi antigens and presents them to T-cell receptors on natural killer T-cells
  • related to the peptide-presenting MHC class I family
  • could be a potential target for modulating NKT activity
  • CD1A, CD1B, CD1C, CD1D bind and present lipid-based antigens to T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterodimer with beta-2-microglobulin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • B2M associated
  • up-regulation of CD1C enhances NKT recognition of CD1D and down-regulation reduces CD1D recognition
  • can act as a sink for the inhibitory receptor LILRB2: when CD1C is up-regulated, LILRB2 is recruited to CD1C, thus reducing the inhibitory effect of LILRB2 on CD1D recognition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS