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FLASH GENE

Symbol

CD1B

contributors: SGE/npt - updated : 12-07-2012

HGNC name	CD1b molecule
HGNC id	1635

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q23.1      Physical location : 158.297.741 - 158.301.321
Synonym name	cell differentiation antigen CD1B,identified by monoclonal antibodies WM-25,4A76,NUT2 (see CD1@)
	CD1B antigen, b polypeptide
	cortical thymocyte antigen CD1B
	differentiation antigen CD1-alpha-3
	T-cell surface glycoprotein CD1b
Synonym symbol(s)	CD1, MGC125990, MGC125991, R1, CD1A

DNA

TYPE	functioning gene
STRUCTURE	3.58 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001764 6 - 1396 NP_001755 - 333 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic thymocyte Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one Ig-like (immunoglobulin-like) domain

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

MHC class I family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
text	late endosomes

basic FUNCTION	antigen-presenting protein, that binds self and non-self lipid and glycolipid Ags and presents them to T-cell receptors on natural killer cells
	presenting lipid A on dendritic cells (Cui 2009)
	related to the peptide-presenting MHC class I family
	CD1A, CD1B, CD1C, CD1D bind and present lipid-based antigens to T cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component	constituent of membrane glycoprotein
	forming heterodimer with beta-2-microglobulin

INTERACTION

DNA

RNA

small molecule

protein	B2M associated
	interacting with saposin C

cell & other

REGULATION

Other

Ag capture is regulated by pH, requiring vesicular acidification to bind lipid antigens (Relloso 2008)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS