Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD180 contributors: mlc - updated : 05-01-2008
HGNC name CD180 antigen
HGNC id 6726
Location 5q12      Physical location : 66.478.103 - 66.492.617
Synonym name lymphocyte antigen 64 homolog, radioprotective 105kDa
Synonym symbol(s) RP105, Ly78, LY64, MGC126233, MGC126234
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     3 Exon(s)
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2697 - 661 - Honda (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 tonsils    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 17 LRR repeats
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer complex
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to lymphocyte antigen 64 (murine)
    ortholog to chimpanzee Ly64
    Homologene
    FAMILY toll-like receptor family
    CATEGORY regulatory , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • implicated in the life/death (apoptosis) decision of B cell
  • involved in signaling of LPS and innate immune response
  • leading to NK-kappa B activation
  • inhibitor of TLR4 by inhibiting its ability to bind microbial ligand
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text innate immunity
    PATHWAY
    metabolism
    signaling
    a component complexed with LY86
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding TLR4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased expression in systemic lupus erythematosus (SLE)
    constitutional       gain of function
    in children with Kawasaki disease or viral infections (higher than in those with bacterial infections or in healthy controls)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS