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FLASH GENE
Symbol CD151 contributors: mct/pgu - updated : 01-06-2011
HGNC name CD151 antigen
HGNC id 1630
Location 11p15.5      Physical location : 832.951 - 838.834
Synonym name
  • cell differentiation antigen CD151
  • hemidesmosomal tetraspanin CD151
  • membrane glycoprotein SFA-1
  • platelet surface glycoprotein gp27
  • platelet-endothelial cell tetraspan antigen 3
  • Synonym symbol(s) PETA3, SFA1, C151, GP27, MER2, PETA-3, RAPH, TSPAN24
    DNA
    TYPE functioning gene
    STRUCTURE 5.88 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC387735 11 similar to Collagen alpha 1(V) chain precursor HRAS 11p15.5 v-Ha-ras Harvey rat sarcoma viral oncogene homolog DKFZp761L1518 11p15.5 hypothetical protein DKFZp761L1518 MGC35138 11p15.5 hypothetical protein MGC35138 C11orf13 11p15,5 chromosome 11 open reading frame 13 KIAA1542 11p15.5 CTD-binding SR-like protein rA9 IRF7 11p15,5 interferon regulatory factor 7 MUCDHL 11p15,5 mucin and cadherin-like SCT 11p15.5 secretin DRD4 11p15.5 dopamine receptor D4 LOC387736 11 LOC387736 DEAF1 11p15,5 deformed epidermal autoregulatory factor 1 (Drosophila) LOC283232 11p15.5 hypothetical protein LOC283232 EPS8L2 11p15.5 EPS8-like 2 TALDO1 11p15.5-p15.4 transaldolase 1 FLJ34283 11p15.5 hypothetical protein FLJ34283 NS3BP 11p15.5 NS3BP BM88 11p15.5 NS3BP SLC25A22 11p15.5 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 LOC387737 11 LOC387737 LRDD 11pter-p15.5 leucine-rich and death domain containing RPLP2 5q31 ribosomal protein, large P2 TTS-2.2 11p15.5 transport-secretion protein 2.2 MGC45840 11p15.5 hypothetical protein MGC45840 CD151 11p15.5 CD151 antigen POLR2L 11p15 polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa TM4SF7 11p15.5 transmembrane 4 superfamily member 7 MGC3234 11p15.5 hypothetical protein MGC3234 AP2A2 11p15.5 adaptor-related protein complex 2, alpha 2 subunit MUC6 11p15.5 mucin 6, gastric LOC387738 11 similar to secreted gel-forming mucin LOC338731 11p15.5 hypothetical LOC338731 LOC387739 11 LOC387739 LOC387740 11 similar to Mucin 2 precursor (Intestinal mucin 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1574 - 253 - 1997 9070943
    8 - 1512 - 253 - 1997 9070943
    9 - 1570 - 253 - 1997 9070943
    8 - 1508 - 253 - 1997 9070943
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain     Homo sapiens
    Respiratorylung   highly
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    Cardiovascularendothelial cell
    Nervousastrocyte Homo sapiens
    Skin/Tegumentkeratinocyte
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four conserved transmembrane domains
  • two extracellular loops and two short cytoplasmic tails
  • a YRSL sequence
  • a YXXphi type of endocytosis/sorting motif, in its C-terminal cytoplasmic domain, playing a key role in signaling
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY TMSF4 family, tetraspanin family
    CATEGORY adaptor , adhesion , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • playing a role in the regulation of cell development, activation, growth and motility
  • functioning as a negative regulator in the adhesion-dependent activation of Ras
  • key component of the glomerular filtration barrier
  • appears to be involved in the establishment, maturation, and/or maintenance of the glomerular basement membrane structure in addition to its role in integrin-mediated adhesion strengthening
  • promotes the formation of epithelial cell-cell contacts in a protein kinase C (PKC) and Cdc42-dependent manner
  • having clearly an important role for HGF-dependent cellular morphogenesis
  • also an important regulator of the stability of tumor cell-cell interactions, potentially through its interaction with alpha3beta1 integrin
  • new role of CD151 in tumorigenesis, whereby it functions as an important regulator of communication between tumor cells and endothelial cells
  • implicated in the regulation of cell-substrate adhesion and cell migration through physical and functional interactions with integrin receptors
  • controls Met-dependent neoplastic growth by enhancing receptor signaling through beta4 integrin-mediated pathways, independent of cell-substrate adhesion
  • 'adaptor' between integrins and signal pathways
  • may plays a specific role in promoting prostate cancer cell motility
  • role in maintenance of the specification state in the trigeminal placode, uncovering the first known role for a tetraspanin in a developmental system
  • implicated in cancer progression and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of hemidesmosomes that anchor epithelial cells to basal lamina
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically associates with integrins (ITGA3B1, ITGA5B1, ITGA6B4)
  • ZDHHC2 associated with CD9 and CD151, but not other cell surface proteins, and protected CD151 and CD9 from lysosomal degradation
  • RNF128 bound to the luminal/extracellular portion of both CD151 and the related tetraspanin CD81 using its PA domain, which promoted ubiquitination of cytosolic lysine residues
  • interacts predominantly with integrins, which is thought to regulate the in
  • out signaling
  • physical association between CD151 and c-Met points to a potential adjunctive function of CD151 in HGF/c-Met signaling
  • cell & other
    REGULATION
    induced by HTLV1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    associated with advanced stage and high nuclear grade in clear cell renal cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • prognostic marker for tumour progression in clear cell renal cell carcinoma patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may be useful as a high-priority therapeutic target for antiangiogenesis in hepatocellular carcinoma
    cancerreproductivebreast
    potentially novel prognostic marker and target for therapy in breast cancer
    ANIMAL & CELL MODELS
  • Cd151-null murine kidneys were severe alterations of the glomerular basement membrane (GBM), reminiscent of Alport syndrome and consisting of massive thickening and splitting of the GBM