Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCT7 contributors: npt/ - updated : 18-06-2004
HGNC name chaperonin containing TCP1, subunit 7 (eta)
HGNC id 1622
Location 2p13.2      Physical location : 73.461.363 - 73.480.149
Synonym name
  • chaperonin containing t-complex polypeptide 1, eta subunit
  • HIV-1 Nef interacting protein
  • T-complex protein 1, eta subunit
  • Synonym symbol(s) Ccth, Nip7-1, CCT-ETA, MGC110985, TCP-1-eta
    DNA
    TYPE functioning gene
    STRUCTURE 18.74 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    P450RAI-2 SEC15L2 2p13.2 SEC15-like 2 (S. cerevisiae) SPR 2p14-p12 sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) LOC388959 2 LOC388959 EMX1 2p13.3 empty spiracles homolog 1 (Drosophila) SFXN5 2p13 sideroflexin 5 GAF1 2p13-p12 gamma-SNAP-associated factor 1 LOC344022 2p13.2 similar to Gnot1 homeodomain protein SMYD5 2p12 SMYD family member 5 C2orf7 2p12 chromosome 2 open reading frame 7 CCT7 2p13.2 chaperonin containing TCP1, subunit 7 (eta) EGR4 2p13 early growth response 4 LOC391387 2 similar to protein 40kD ALMS1 2p13 Alstrom syndrome 1 NAT8 2p13-1-p12 N-acetyltransferase 8 (camello like) LOC200420 2p13.1 LOC200420 CML2 2p13.1 putative N-acetyltransferase Camello 2 CGI-121 2p24.3-p24.1 CGI-121 protein DUSP11 2p13 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) LOC388960 2 similar to hypothetical protein 4921507A12 AMSH ACTG2 2p13.1 actin, gamma 2, smooth muscle, enteric DGUOK 2p24.3-p24.1 deoxyguanosine kinase LOC388961 2 LOC388961 MGC22014 2p13.1 hypothetical protein MGC22014 MGC10955 2p13.1 hypothetical protein MGC10955 LOC388962 2 similar to RIKEN cDNA 1810056O20 C2orf6 2p12 chromosome 2 open reading frame 6 MTHFD2 2p12 methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase SLC4A5 2p13 solute carrier family 4, sodium bicarbonate cotransporter, member 5 DCTN1 2p13 dynactin 1 (p150, glued homolog, Drosophila) LOC388963 2 similar to Retinol dehydrogenase 12 LOC257200 2p13.1 similar to high mobility group AT-hook 1 FLJ12953 2p13.1 hypothetical protein FLJ12953 similar to Mus musculus D3Mm3e RTKN 2p13 rhotekin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1948 - 543 - Guo (2005)
    7 - 1336 - 339 - Guo (2005)
    - - 1687 - 456 - Guo (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineadrenal gland   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Cct7
    homolog to rattus LOC297406
    Homologene
    FAMILY
  • TCP-1 chaperonin family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • soluble guanylyl cyclase-interacting protein, that assist the folding of proteins upon ATP hydrolysis
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • interacting with GUCY1A2 and GUCY1B2 (in cooperation with some other factor, inhibits its activity by modifying the binding of Nitric oxide to the heme group or the subsequent conformational changes)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS