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FLASH GENE
Symbol CCT6A contributors: mct/npt/pgu - updated : 27-03-2013
HGNC name chaperonin containing TCP1, subunit 6A (zeta 1)
HGNC id 1620
Location 7p11.2      Physical location : 56.119.377 - 56.131.682
Synonym name
  • histidine transport regulator 3
  • T-complex protein 1, zeta subunit
  • amino acid transport defect-complementing
  • acute morphine dependence related protein 2
  • Synonym symbol(s) TCP20, HTR3, CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MGC126214, MGC126215, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20
    DNA
    TYPE functioning gene
    STRUCTURE 12.31 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392908 7 similar to KIAA0565 protein FKBP9L 7p11.1 FK506 binding protein 9-like DKFZP564K0822 7p11.2 hypothetical protein DKFZp564K0822 LOC392674 7 similar to SMT3 suppressor of mif two 3 homolog 2 LOC392675 7 similar to hypothetical protein LOC349114 LOC392909 7 similar to septin 10 isoform 1 LOC392032 7 similar to cell division cycle 42 isoform 2; cell division cycle 42 (GTP-binding protein, 25kD); GTP-binding protein, 25kD; cell division cycle 42 (GTP binding protein, 25kD) LOC392033 7 similar to tubulin, beta 5 FLJ39963 7p11.2 hypothetical protein FLJ39963 LOC392034 7 similar to KIAA0565 protein FKBP9L 7p11.1 FK506 binding protein 9-like MRPS17 7p11-q11.21 mitochondrial ribosomal protein S17 GBAS 7p12 glioblastoma amplified sequence LOC389491 7 similar to SMT3 suppressor of mif two 3 homolog 2 LOC389492 7 similar to hypothetical protein LOC349114 PSPH 7p15 phosphoserine phosphatase CCT6A 7q32-q33 chaperonin containing TCP1, subunit 6A (zeta 1) LOC346288 7p11.2 similar to septin 10 isoform 1 SUMF2 7q11.1 sulfatase modifying factor 2 PHKG1 7p12-q21 phosphorylase kinase, gamma 1 (muscle) C7orf17 7p11.2 chromosome 7 open reading frame 17 LOC392676 7 similar to Protein p8 (Candidate of metastasis 1) LOC392910 7 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) FLJ39963 7p11.2 hypothetical protein FLJ39963 LOC392677 7 hypothetical gene supported by NM_007235 MRPS17 7p11-q11.21 mitochondrial ribosomal protein S17 GBAS 7p12 glioblastoma amplified sequence PSPH 7p15 phosphoserine phosphatase CCT6A 7q32-q33 chaperonin containing TCP1, subunit 6A (zeta 1) SUMF2 7q11.1 sulfatase modifying factor 2 PHKG1 7p12-q21 phosphorylase kinase, gamma 1 (muscle) C7orf17 7p11.2 chromosome 7 open reading frame 17 LOC392678 7 similar to hypothetical protein LOC349114 LOC389493 7 similar to Protein p8 (Candidate of metastasis 1) LOC392035 7 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) LOC392679 7 similar to KIAA1074 protein LOC340232 7p11.2 similar to Exportin T (tRNA exportin) (Exportin(tRNA)) LOC392911 7 similar to zinc finger protein 43 (HTF6) DKFZp434L192 7p11.2 hypothetical protein DKFZp434L192 LOC392912 7 similar to hypothetical protein 9630041N07 LOC392680 7 LOC392680 LOC154937 7p11.2 protein phosphatase 2, regulatory subunit B (B56), epsilon isoform pseudogene LOC392913 7 hypothetical gene supported by AF117108 LOC389494 7 similar to hypothetical protein LOC349114 LOC392914 7 similar to zinc finger protein 43 (HTF6) LOC254027 7p11.2 similar to KIAA1074 protein LOC392915 7 similar to zinc finger protein 43 (HTF6) LOC392036 7 similar to zinc finger protein 43 (HTF6) DKFZp434L192 7p11.2 hypothetical protein DKFZp434L192 LOC392037 7 similar to hypothetical protein 9630041N07 LOC389495 7 LOC389495 LOC392916 7 similar to capicua homolog LOC392681 7 LOC392681
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2682 - 531 - 2005 16236267
    13 - 2547 - 486 - 2005 16236267
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivefemale systemuterus  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    ATP-binding sites perfectly conserved among mammals and yeast
    mono polymer heteromer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae
    Homologene
    FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating ATP-dependent monomeric protein folding
  • molecular chaperone that assists the folding of proteins upon ATP hydrolysis
  • required for maturation of sphingosine kinase 1
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin
  • might play an essential role in modulation of folding of polyglutamine expanded proteins and could be another target for further therapeutic studies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex, subunits of the CCT complex involved in ATP-dependent folding of cellular proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with androgen receptor (AR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS