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FLASH GENE
Symbol CCT6A contributors: mct/npt/pgu - updated : 27-03-2013
HGNC name chaperonin containing TCP1, subunit 6A (zeta 1)
HGNC id 1620
Location 7p11.2      Physical location : 56.119.377 - 56.131.682
Synonym name
  • histidine transport regulator 3
  • T-complex protein 1, zeta subunit
  • amino acid transport defect-complementing
  • acute morphine dependence related protein 2
  • Synonym symbol(s) TCP20, HTR3, CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MGC126214, MGC126215, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20
    DNA
    TYPE functioning gene
    STRUCTURE 12.31 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2682 - 531 - 2005 16236267
    13 - 2547 - 486 - 2005 16236267
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivefemale systemuterus  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    ATP-binding sites perfectly conserved among mammals and yeast
    mono polymer heteromer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae
    Homologene
    FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating ATP-dependent monomeric protein folding
  • molecular chaperone that assists the folding of proteins upon ATP hydrolysis
  • required for maturation of sphingosine kinase 1
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin
  • might play an essential role in modulation of folding of polyglutamine expanded proteins and could be another target for further therapeutic studies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex, subunits of the CCT complex involved in ATP-dependent folding of cellular proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with androgen receptor (AR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS