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FLASH GENE
Symbol CCT4 contributors: mct/npt - updated : 26-03-2008
HGNC name chaperonin containing TCP1, subunit 4 (delta)
HGNC id 1617
Location 2p15      Physical location : 62.095.262 - 62.115.791
Synonym name
  • chaperonin containing t-complex polypeptide 1, delta subunit
  • stimulator of TAR RNA binding protein
  • Synonym symbol(s) SRB, Cctd, MGC126164, MGC126165, CCT-delta
    DNA
    TYPE functioning gene
    STRUCTURE 20.53 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC130839 2p16.1 hypothetical gene LOC130839 BCL11A 2p15 B-cell CLL/lymphoma 11A (zinc finger protein) LOC130865 2p16.1 similar to 60S RIBOSOMAL PROTEIN L26 ATP1B3P1 2p13-p15 ATPase, Na+/K+ transporting, beta 3 pseudogene PAPOLG 2p15 poly(A) polymerase gamma REL 2p12 v-rel reticuloendotheliosis viral oncogene homolog (avian) LOC344423 2p16.1 similar to ribosomal protein S12 FLJ32312 2p16.1 hypothetical protein FLJ32312 PEX13 2p16-p14 peroxisome biogenesis factor 13 KIAA1841 2q14 KIAA1841 protein LOC339804 2p16.1 hypothetical gene supported by AK075484; BC014578 AHSA2 2p16.1-p15 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) USP34 2p14 ubiquitin specific protease 34 XPO1 2p16 exportin 1 (CRM1 homolog, yeast) LOC391376 2 similar to 60S ribosomal protein L14 (CAG-ISL 7) FLJ13305 2p15 hypothetical protein FLJ13305 CCT4 2p13.3 chaperonin containing TCP1, subunit 4 (delta) C2orf5 2p15 chromosome 2 open reading frame 5 (MURR1) LOC388954 2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) B3GNT1 2p14 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 FLJ34583 KIAA0903 2p15 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 OTX1 2p13 orthodenticle homolog 1 (Drosophila) LOC51057 2p15 hypothetical protein LOC51057 MDH1 2p16 malate dehydrogenase 1, NAD (soluble) LOC388955 2 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) LOC391377 2 similar to ribosomal protein S4 LOC391378 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) UGP2 2p14-p13 UDP-glucose pyrophosphorylase 2 VPS54 2p13-p14 vacuolar protein sorting 54 (yeast) PELI1 2p13.3 pellino homolog 1 (Drosophila) LOC130773 2p15 similar to 60S ribosomal protein L23a
    regionally located in the PARK3 region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2349 - 539 - Chi (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrineparathyroid   highly
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer
    HOMOLOGY
    Homologene
    FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • assembled into a TCP-1ring and mediating ATP-dependent monomeric protein folding
  • chaperonin required for the maturation of cyclin E and involved in folding tubulin, actin and other cytosolic proteins
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex (970kDa)
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS