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FLASH GENE
Symbol CCT3 contributors: mct/npt - updated : 26-03-2008
HGNC name chaperonin containing TCP1, subunit 3 (gamma)
HGNC id 1616
Location 1q22      Physical location : 156.278.751 - 156.308.206
Synonym name
  • TCP1 ring complex, molecular chaperone involved in actin and tubulin folding
  • chaperonin containing TCP1, subunit 3
  • T-complex protein 1, gamma subunit
  • TCP1 (t-complex-1) ring complex, polypeptide 5
  • Synonym symbol(s) TRIC5, CCTG, CCT-gamma, TCP-1-gamma
    DNA
    TYPE functioning gene
    STRUCTURE 29.44 kb     14 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    YAP 1q21.3 SH2 domain protein 2A DAP3 1q21 death associated protein 3 LOC388705 1 similar to misato FLJ20203 1q22 hypothetical protein FLJ20203 SYT11 1q21.2 synaptotagmin XI RIT1 1q21.2 Ras-like without CAAX 1 KIAA0907 1q21 Ras-like without CAAX 1 GPR100 1q22 G protein-coupled receptor 100 ARHGEF2 1q11-q21 rho/rac guanine nucleotide exchange factor (GEF) 2 SSR2 1q21-q23 signal sequence receptor, beta (translocon-associated protein beta) C1orf6 1q21 chromosome 1 open reading Frame 6 MAPBPIP 1q22 mitogen-activated protein-binding protein-interacting protein RAB25 1q21.2 RAB25, member RAS oncogene family LOC92312 1q22-q23.1 hypothetical protein LOC92312 LMNA 1q21.2-q21.3 lamin A/C FLJ12287 1q22 hypothetical protein FLJ12287 similar to semaphorins LOC388706 1 LOC388706 KIAA0446 1q23.1 KIAA0446 gene product PMF1 1q12-q21.1 polyamine-modulated factor 1 BGLAP 1q25-q31 bone gamma-carboxyglutamate (gla) protein (osteocalcin) PAQR6 1q23.1 progestin and adipoQ receptor family member VI EST1B 1q21.2 Est1p-like protein B MGC13102 1q23.1 hypothetical protein MGC13102 MGC31963 1q23.1 kidney predominant protein NCU-G1 LOC391104 1 similar to Von Hippel-Lindau disease tumor suppressor (pVHL) (G7 protein) CCT3 1q23 chaperonin containing TCP1, subunit 3 (gamma) SSTK-IP 1q23.1 SSTK-interacting protein RHBG 1q21.3 Rhesus blood group, B glycoprotein CROC4 1q12-q25 Rhesus blood group, B glycoprotein MEF2D 1q12-q23 MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) IQGAP3 1q21.3 IQ motif containing GTPase activating protein 3 LOC164118 1q23.1 similar to RIKEN cDNA A430025D11 APOA1BP 1q21.2 apolipoprotein A-I binding protein FLJ20249 1q22 hypothetical protein FLJ20249 BRAL1 1q22 hypothetical protein FLJ20249 BCAN 1q23-q31 hypothetical protein FLJ20249 NES 1q23.1 nestin CRABP2 1q21.3 cellular retinoic acid binding protein 2 FLJ12671 1q23.1 hypothetical protein FLJ12671 CGI-41 1q23.1 CGI-41 protein MRPL24 1q21-q22 mitochondrial ribosomal protein L24 HDGF Xq25 hepatoma-derived growth factor (high-mobility group protein 1-like) PRCC 1q21.2 papillary renal cell carcinoma (translocation-associated) SH2D2A 1q21 SH2 domain protein 2A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2096 - 545 - Wong, Gregory (2006)
    14 - 2093 - 544 - Wong, Gregory (2006)
    12 - 1982 - 507 - Wong, Gregory (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text pharyngeal arch 1
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , oligo
    HOMOLOGY
    Homologene
    FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • mediating ATP-dependent monomeric protein folding
  • playing a role in the assembly of the von hippel- lindau ubiquitylation complex
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS