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FLASH GENE
Symbol CCT2 contributors: mct/npt - updated : 26-03-2008
HGNC name chaperonin containing TCP1, subunit 2 (beta)
HGNC id 1615
Location 12q15      Physical location : 69.979.207 - 69.995.357
Synonym name
  • T-complex protein 1, beta subunit
  • chaperonin containing t-complex polypeptide
  • Synonym symbol(s) 99D8.1, CCT-beta, CCTB, MGC142074, MGC142076, PRO1633, TCP-1-beta
    DNA
    TYPE functioning gene
    STRUCTURE 16.15 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Map cen - D12S83 - AVPR1A - D12S324 - D12S1702 - D12S335 - MDM2 - LYZ - CCT2 ,CPM - D12S80 - D12S344 - D12S350 - qter
    Authors Gene Map (98)
    Physical map
    DYRK2 12q14.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 LOC341333 12q14.3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) IFNG 12q14-q15 interferon, gamma IL26 12q15 interleukin 26 IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M CPSF6 12q13.2 cleavage and polyadenylation specific factor 6, 68kDa LYZ 12q14-q15 lysozyme (renal amyloidosis) GAS41 12q13-q15 lysozyme (renal amyloidosis) FRS2 12q15 fibroblast growth factor receptor substrate 2 CCT2 12q15 chaperonin containing TCP1, subunit 2 (beta) LOC387868 12 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 VMD2L3 12q14.2-q15 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 MGC13168 12q14.3 hypothetical protein MGC13168 RAB3IP 12q13-q15 RAB3A interacting protein (rabin3) FLJ25056 12q14.3 hypothetical protein FLJ25056 CNOT2 12q13.2 CCR4-NOT transcription complex, subunit 2 KCNMB4 12q14.1-q15 potassium large conductance calcium-activated channel, subfamily M, beta member 4 LOC390342 12 similar to Gag-Pro-Pol-Env protein PTPRB 12q15 protein tyrosine phosphatase, receptor type, B PTPRR 12q13.2-q13.3 protein tyrosine phosphatase, receptor type, R TM4SF3 12q14.1-q21.1 transmembrane 4 superfamily member 3 GPR49 12q22-q23 G protein-coupled receptor 49 MGC23401 12q15 hypothetical protein MGC23401
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 1962 - 535 - Guo (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineneuroendocrinepituitary  highly
    Reproductivemale systemtestis  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer
    HOMOLOGY
    Homologene
    FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • assembled into a TCP1 ring and mediating ATP-dependent monomeric protein folding
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex (970kDa)
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS