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FLASH GENE
Symbol CCR7 contributors: mct - updated : 05-02-2015
HGNC name chemokine (C-C motif) receptor 7
HGNC id 1608
Location 17q21.2      Physical location : 38.710.022 - 38.721.736
Synonym name
  • Epstein Barr virus induced gene 1
  • MIP-3 beta receptor
  • CD197 antigen
  • lymphocyte-specific G protein-coupled peptide receptor
  • Synonym symbol(s) CMKBR7, EBI1, BLR2, CDw197, EVI1, CD197, CC-CKR-7, CCR-7
    DNA
    TYPE functioning gene
    STRUCTURE 11.72 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PSMD3 17q21.1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 CSF3 17q11.2-q12 colony stimulating factor 3 (granulocyte) TRAP100 THRA 17q11.2 thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) NR1D1 17q11.2 nuclear receptor subfamily 1, group D, member 1 MLN51 17q12-q21.3 nuclear receptor subfamily 1, group D, member 1 LOC339287 17q21.2 hypothetical protein LOC339287 Link-GEFII 17q21.2 Link guanine nucleotide exchange factor II WIRE 17q21.2 WIRE protein CDC6 17q21.3 CDC6 cell division cycle 6 homolog (S. cerevisiae) RARA 17q12 retinoic acid receptor, alpha GJC1 17q21.1 gap junction protein, chi 1, 31.9kDa (connexin 31.9) LOC390791 17 similar to peptidyl-Pro cis trans isomerase TOP2A 17q21.31 topoisomerase (DNA) II alpha 170kDa IGFBP4 17q12 insulin-like growth factor binding protein 4 CTEN 17q21.2 C-terminal tensin-like LOC284134 17q21.2 hypothetical LOC284134 CCR7 17q21.1 chemokine (C-C motif) receptor 7 SMARCE1 17q21.1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 MGC45562 17q21.2 hypothetical protein MGC45562 KRT24 17q11.2 keratin 24 KRT25B 17q21.2 keratin 25B KRT25A 17q21.2 keratin 25A KRT25C 17q21.2 keratin 25C KRT25D 17q21.2 keratin 25C MGC21518 17q21.2 hypothetical protein MGC21518 KRT12 17q21.1 keratin 12 (Meesmann corneal dystrophy) KRT20 17q21.2 keratin 20 KRT23 17q21.2 keratin 23 (histone deacetylase inducible) LOC390792 17 similar to type I hair keratin 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2207 40.2 378 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil Homo sapiens
    Blood/Hematopoieticneutrophil Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus binds to the N-loop and third beta-strand of CCL21 chemokine domain
  • seven transmembrane segments (7TM) receptor
  • lysine 564 adjacent to the C-terminal binding protein-binding motif is crucial for transcriptional activation of GATA2
  • HOMOLOGY
    interspecies homolog to rattus Ccr7 (86.2pc)
    homolog to murine ccr7 (87.0pc)
    Homologene
    FAMILY
  • G protein coupled receptor/chemokine receptor family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    basic FUNCTION
  • probable mediator of EBV effects on B lymphocytes or of normal lymphocyte functions
  • activating B and T lymphocytes
  • controls migration of memory T cells to inflamed tissues and stimulate dendritic cell maturation
  • promotes metastasis by preventing anoikis in cancer cells
  • is the essential adhesion signal required for the targeting of leukaemic T-cells into the CNS
  • CCR7 and CCL21 contribute to the migratory capacity of the dendritic cells
  • directly activates GATA2 transcription, which is an important gene for the maintenance of hematopoietic stem cells
  • CCR7 mediates entry into the lymph nodes and S1PR1 signaling controls their subsequent exit
  • CCR7-independent transport of skin self-Ags occurs in the dermis
  • eosinophils express CCR7 and have multipotent responses to the known ligands of CCR7
  • playing no appreciable role in trafficking of central memory CD4 T cells to lymph nodes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text inflammatory response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for the MIP-3-beta chemokine (CCL19)
  • high affinity for CCL21
  • chemokine receptor involved in the migration of neutrophils to the lymph nodes
  • CCR7 was found to interact directly with TOPI
  • CCL21 chemokine recruits normal immune cells and metastasizing tumor cells to lymph nodes through activation of the G protein-coupled receptor CCR7
  • after binding to CCL19, CCR7 signaling leads to increased expression and phosphorylation of MAPK7 and up-regulation of KLF2, which results in S1PR1 expression and a migration of T lymphocytes
  • contribution of CCR7 to STAP2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells
  • RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs
  • cell & other
    REGULATION
    induced by Epstein-Barr virus
    Other expression is controlled by the activity of Notch1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells, malignant breast tumors and metastases
    tumoral     --over  
    in muscle fibers in juvenile dermatomyositis
    constitutional     --over  
    of CCL5 and median chemokine receptor 7 (CCR7) mRNA expression in localized scleroderma lesions as compared to healthy controls
    tumoral     --over  
    significantly increased in gastric adenocarcinomas compared to peritumoral tissue
    constitutional     --over  
    exacerbates atherosclerosis by increasing T cell accumulation in atherosclerotic lesions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target CCL21/CCR7 signaling of fibrocytes may provide therapeutic targets for combating renal fibrosis
    ANIMAL & CELL MODELS
  • CCR7-/- mice exhibit profound anomalies in lymph node and spleen architecture, which complicates the study of CCR7-mediated T cell trafficking