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FLASH GENE
Symbol CCNY contributors: mct - updated : 07-02-2014
HGNC name cyclin Y
HGNC id 23354
Location 10p11.21      Physical location : 35.535.952 - 35.860.845
Synonym name
  • cyclin fold protein 1
  • cyclin-box carrying protein 1
  • chromosome 10 open reading frame 9
  • Synonym symbol(s) CFP1, CBCP1, C10orf9, CCNX, FLJ95513
    DNA
    TYPE functioning gene
    STRUCTURE 325.69 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3968 39 341 - -
  • isoform 1
  • 12 - 3948 - 287 - -
  • isoform 2
  • 11 - 4774 - 287 - -
    8 - 4574 - 208 - -
    9 - 4636 - 316 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Lymphoid/Immunethymus   highly
    Nervousbraindiencephalonhypothalamus  
    Reproductivemale systemtestis  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cyclin domain
  • HOMOLOGY
    interspecies homolog to murine Ccny (98.2pc)
    homolog to rattus Ccny (97.9pc)
    Homologene
    FAMILY
  • cyclin family
  • cyclin Y subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • controls cell division cycles and regulates cyclin-dependent kinases (18060517)
  • might play an important role in glioma tumorigenisis
  • role of CCNY as a clinically relevant human oncoprotein
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the SETD1A complex, including CCNY, RBBP5, ASH2L, WDR5, and WDR82, associating with SETD1B (Lee 2007)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCNY, was identified as a CDK14 interacting protein
  • binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PRKACA phosphorylation site
  • by binding to N-myristoylated CCNY, CDK16 is targeted to the plasma membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Crohn's disease (Henckaerts 2009)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS