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FLASH GENE
Symbol CCNO contributors: mct - updated : 08-10-2014
HGNC name cyclin O
HGNC id 18576
Corresponding disease
ICS30 immotile cilia syndrome 30
Location 5q11.2      Physical location : 54.526.982 - 54.529.508
Synonym name
  • uracil-DNA glycosylase 2
  • cyclin U
  • cyclin-like uracil-DNA glycosylase
    • Synonym symbol(s) FLJ22422, UDG2, UNG2, CCNU
    EC.number 3.2.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 2.53 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1448 38 350 - 2013 23515676
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  highly Homo sapiens
     female systemuteruscervix highly
    Urinarybladder   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cyclin family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • excise uracil from DNA
  • coordinate the initial steps of base excision repair by distinct mechanisms and is apparently adapted to rapid and highly coordinated repair of uracil (U:G and U:A) in replicating DNA
  • initiate error-free BER in most DNA contexts, but is also involved in mutagenic processing of activation-induced cytosine deaminase (AID)-induced uracil during the antibody diversification process
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MCIDAS is a key regulator of CCNO/FOXJ1 for human multiciliated cell differentiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS30
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS