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FLASH GENE
Symbol CCNL2 contributors: SGE/npt - updated : 12-07-2017
HGNC name cyclin L2
HGNC id 20570
Location 1p36.33      Physical location : 1.321.090 - 1.334.718
Synonym name
  • cyclin M
  • paneth cell-enhanced expression protein
  • Synonym symbol(s) ania-6b, PCEE, SB138, HLA-ISO, DKFZp761A1210, DKFZp762O195, CCNM, HCLA-ISO
    DNA
    TYPE functioning gene
    STRUCTURE 13.63 kb     13 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3136 - 520 - -
  • also called L2alpha or T2
  • isoform A
  • 13 - 1237 - 226 - -
  • also called L2betaA3 or T3
  • isoform B
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two RNA recognition motif (rrm) domains
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ccnl2 (90.3pc)
    Homologene
    FAMILY
  • cyclin family, cyclin L subfamily
  • splicing factor sr family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • transcriptional regulator which particpates in regulating the pre-mRNA splicing process
  • also modulating the expression of critical apoptotic factor, leading to cell apoptosis
  • inducing apoptosis of hepatocellular carcinoma cells (Yang 2004)
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CDC2L1 or CDC2L2 (Loyer 2008)
  • interacting with SFRS2, SFRS7, and POLR2A, the hyperphosphorylated C-terminal domain of RNA pol II
  • cell & other
    REGULATION
    Other phosphorylated by DYRK1A (de Graaf 2004)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS