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FLASH GENE
Symbol CCNL1 contributors: mct/pgu - updated : 04-02-2012
HGNC name cyclin L1
HGNC id 20569
Location 3q25.31      Physical location : 156.865.587 - 156.878.482
Synonym name
  • cyclin L ania-6a
  • cyclin L gamma
  • Synonym symbol(s) BM-001, CCNL, PRO1073, ania-6a
    DNA
    TYPE functioning gene
    STRUCTURE 12.91 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2625 - 526 - 2008 18216018
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C terminal dipeptide repeat of alternating arginines and serines (a hallmark of the SR family of splicing factor), C-terminal arginine and serine-rich (RS) domain
  • a characteristic cyclin box
  • HOMOLOGY
    interspecies ortholog to murine Ccnl
    homolog to Drosophila EG:67A9.2
    homolog to C.elegans C52E4.6a
    Homologene
    FAMILY
  • cyclin family
  • cyclin L subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • localized in the splicing factor compartment (nuclear speckles)
  • with TFIP11 and EWSR1 frequently co-localize to speckled nuclear domains
  • basic FUNCTION
  • involved in regulation of RNA polymerase 2 transcription
  • with TFIP11 and EWSR1, participate in a common cellular activity related to RNA splicing events
  • may be involved in pre-mRNA splicing and RNA processing and associates with cyclin-dependent kinases
  • may be implicated in fetal growth and birth weight variation
  • plays a critical role in loco-regional progression and may serve as an indicator for occult advanced tumor stages
  • has a negative effect on breast cancer cell growth and may play an important role in controlling the growth of breast cancer
  • may have a special role in the regulation of the cell cycle
  • CELLULAR PROCESS cell cycle, division
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • immobile component of the splicing factor compartment
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to p110 PITSLRE kinase
  • cyclin-dependent kinase and cyclin partner of CDK12 and regulate alternative splicing
  • interacting with CDC2L6
  • fine balance between CCNL1 and TIMP1, which may contribute to breast cancer development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in uterine cervical carcinoma
    tumoral     --over  
    CCNL1 and TIMP1 expression was significantly elevated in breast cancer tissues compared with that in peri-breast cancer tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS