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FLASH GENE

Symbol

CCNL1

contributors: mct/pgu - updated : 04-02-2012

HGNC name	cyclin L1
HGNC id	20569

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q25.31      Physical location : 156.865.587 - 156.878.482
Synonym name	cyclin L ania-6a
	cyclin L gamma
Synonym symbol(s)	BM-001, CCNL, PRO1073, ania-6a

DNA

TYPE	functioning gene
STRUCTURE	12.91 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020307 11 - 2625 NP_064703 - 526 - 2008 18216018

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Lymphoid/Immune spleen       highly   thymus       highly Nervous brain         Reproductive male system prostate       Respiratory respiratory tract trachea     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a C terminal dipeptide repeat of alternating arginines and serines (a hallmark of the SR family of splicing factor), C-terminal arginine and serine-rich (RS) domain
	a characteristic cyclin box

HOMOLOGY

interspecies	ortholog to murine Ccnl
	homolog to Drosophila EG:67A9.2
	homolog to C.elegans C52E4.6a

Homologene

FAMILY	cyclin family
	cyclin L subfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	localized in the splicing factor compartment (nuclear speckles)
	with TFIP11 and EWSR1 frequently co-localize to speckled nuclear domains

basic FUNCTION	involved in regulation of RNA polymerase 2 transcription
	with TFIP11 and EWSR1, participate in a common cellular activity related to RNA splicing events
	may be involved in pre-mRNA splicing and RNA processing and associates with cyclin-dependent kinases
	may be implicated in fetal growth and birth weight variation
	plays a critical role in loco-regional progression and may serve as an indicator for occult advanced tumor stages
	has a negative effect on breast cancer cell growth and may play an important role in controlling the growth of breast cancer
	may have a special role in the regulation of the cell cycle

CELLULAR PROCESS	cell cycle, division
	nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

immobile component of the splicing factor compartment

INTERACTION

DNA

RNA

small molecule

protein	binding to p110 PITSLRE kinase
	cyclin-dependent kinase and cyclin partner of CDK12 and regulate alternative splicing
	interacting with CDC2L6
	fine balance between CCNL1 and TIMP1, which may contribute to breast cancer development

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in uterine cervical carcinoma tumoral     --over   CCNL1 and TIMP1 expression was significantly elevated in breast cancer tissues compared with that in peri-breast cancer tissues

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS