Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCNK contributors: npt/mct - updated : 17-10-2018
HGNC name cyclin K
HGNC id 1596
Corresponding disease
MRSFD mental retardation syndromic with facial dysmorphism
Location 14q32.2      Physical location : 99.947.738 - 99.977.851
Synonym symbol(s) CPR4, MGC9113
DNA
TYPE functioning gene
STRUCTURE 30.11 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2618 - 580 - 2018 29760377
9 - 1945 - 354 - 2018 29760377
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Reproductivefemale systemovary   
 female systembreastmammary gland highly
 male systemtestis  highly Homo sapiens
Visualeye   highly
cell lineage most abundant in developing germ cells of adult testis and ovary
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • possessing both C terminal domain kinase
  • Cdk activating kinase activity
  • HOMOLOGY
    Homologene
    FAMILY
  • cyclin family
  • cyclin C subfamily
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • RNA polymerase II associated cyclin phosphorylating its C-terminal domain also regulating CDK9
  • may play a dual role by regulating CDK and transcription
  • may play a role in regulating the cell cycle or apoptosis after being targeted for transcription by TP53
  • direct role for CDK9–CCNK in checkpoint pathways that maintain genome integrity in response to replication stress
  • mediates the replication stress response functions of CDK9
  • is essential for embryonic stem cell maintenance
  • may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance
  • plays a critical role in transcriptional regulation as well as cell development
  • is thought to play a critical role in the RNA polymerase II-mediated activities
  • is a regulator of neurodevelopment
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text basal transcription
    PATHWAY
    metabolism
    signaling
    a component
  • CDK9–CCNK complex has different biological activities to the CDK9–CCNT1 complex
  • complexing with CDK12
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK9
  • CDK9 and CCNK interact with ataxia telangiectasia and Rad3-related protein and other checkpoint signalling proteins
  • CDK9 binds to cyclin K , and direct role of CDK9-CCNK in pathways that maintain genome integrity in response to replication stress appear to be evolutionarily conserved
  • interaction of CDK12 with CCNK is required for the phosphorylation of the C-terminal domain of RNA polymerase II
  • CDK12/CCNK prefers a substrate with unmodified repeats or one that mimics prephosphorylation at the S7 position of the CTD
  • CCNK-dependent, novel phosphorylation site in cyclin E1 that disrupts its interaction with CDK2
  • cell & other
    REGULATION
    activated by TP53 in response to DNA damage
    ASSOCIATED DISORDERS
    corresponding disease(s) MRSFD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a putative predictive biomarker for clinical outcome and therapy response for patients with prostate cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting CCNK represents a novel, promising anti-cancer strategy to induce cell cycle arrest and apoptotic cell death through induction of mitotic catastrophe in prostate cancer cells
    ANIMAL & CELL MODELS