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FLASH GENE
Symbol CCNI contributors: mct - updated : 24-06-2016
HGNC name cyclin I
HGNC id 1595
Location 4q21.1      Physical location : 77.969.178 - 77.997.125
Synonym name cyclin ITI
Synonym symbol(s) CYC1, CYI, CYC1, CCNI1
DNA
TYPE functioning gene
STRUCTURE 28.86 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ23657 4q21.21 hypothetical protein FLJ23657 CDKL2 4q21.21 cyclin-dependent kinase-like 2 (CDC2-related kinase) G3BP2 4q12-q21.1 cyclin-dependent kinase-like 2 (CDC2-related kinase) VDP 4q21.1 vesicle docking protein p115 PPEF2 4q13-q21 protein phosphatase, EF hand calcium-binding domain 2 ASAHL 4q21.1 N-acylsphingosine amidohydrolase (acid ceramidase)-like FLJ10498 4q21.21 hypothetical protein FLJ10498 CXCL9 4q21.2 chemokine (C-X-C motif) ligand 9 CXCL10 4q21.2 chemokine (C-X-C motif) ligand 10 CXCL11 4q21.2 chemokine (C-X-C motif) ligand 11 ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2 CXCL13 4q21 chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) CNOT6L 4q13.3 CCR4-NOT transcription complex, subunit 6-like MRPL1 4q21.1 mitochondrial ribosomal protein L1 LOC391670 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FRAS1 4q21.21 Fraser syndrome 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1890 - 377 - 1998 9705831
- - 1443- - 178 in testis, at increased level compared to other tissues 1998 9705831
  • first ATG Met start codon at nt 1 and has the well-conserved sequence of cyclin box
  • three amino acids mutations at nt 25, 172, 223, respectively, including one in the well-conserved sequence of cyclin box
  • may have a physiological role in spermatogenesis and/or human sperm cell function--especially in capacitation and/or acrosome reaction
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunetonsils   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY cyclin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may have a physiological role in spermatogenesis and/or human sperm cell function--especially in capacitation and/or acrosome reaction
  • protects podocytes from apoptosis, and likely this is mediated by stabilization of CDKN1A
  • activators of CDK5, CDK5R1, and CCNI are not required for normal kidney function, but, they play pivotal coordinated roles in maintaining podocyte survival during stress states in disease
  • has a role in the regulation of cell cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK5 is activated by both CCNI and the noncyclin activator CDK5R1 in terminally differentiated cells such as kidney podocytes and neurons
  • interaction between Cyclin I and CDK5 was detected in cells overexpressed with both proteins
  • predominance of CCNI mediates the nuclear localization of CDK5, whereas the predominance of CDK5R1 results in a membranous localization of CDK5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS