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FLASH GENE
Symbol CCNG2 contributors: mct - updated : 27-10-2012
HGNC name cyclin G2
HGNC id 1593
Location 4q21.1      Physical location : 78.078.356 - 78.091.210
Synonym symbol(s) CycG2
DNA
TYPE functioning gene
STRUCTURE 12.86 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site   HRE
text structure
  • a responsive region containing a half-estrogen response element and GC-rich region that interact with ESR1 and Sp1 proteins
  • several putative FOXO3-binding sites are present in the promoter and overexpression of FOXO3 enhanced the CCNG2 promoter activity
    • MAPPING cloned Y linked N status provisional
    Physical map
    CDKL2 4q21.21 cyclin-dependent kinase-like 2 (CDC2-related kinase) G3BP2 4q12-q21.1 cyclin-dependent kinase-like 2 (CDC2-related kinase) VDP 4q21.1 vesicle docking protein p115 PPEF2 4q13-q21 protein phosphatase, EF hand calcium-binding domain 2 ASAHL 4q21.1 N-acylsphingosine amidohydrolase (acid ceramidase)-like FLJ10498 4q21.21 hypothetical protein FLJ10498 CXCL9 4q21.2 chemokine (C-X-C motif) ligand 9 CXCL10 4q21.2 chemokine (C-X-C motif) ligand 10 CXCL11 4q21.2 chemokine (C-X-C motif) ligand 11 ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2 CXCL13 4q21 chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) CNOT6L 4q13.3 CCR4-NOT transcription complex, subunit 6-like MRPL1 4q21.1 mitochondrial ribosomal protein L1 LOC391670 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FRAS1 4q21.21 Fraser syndrome 1 ANXA3 4q13-q22 annexin A3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5489 - 344 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   moderately
     thymus   predominantly
    Nervousbrain   highly
    Reproductivefemale systemuterus  moderately
     male systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    cell cycle     cell cycle, S
    Text
  • placenta
  • increasing through the cell cycle to peak in the mid/late-S phase and decrease during G2/M phase
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-terminal PEST protein destabilization motif
  • a potential Shc PTB binding site
  • a 100 AA C-terminal region of cyclin G2 is sufficient to both direct GFP localization to centrosomes and induce cell cycle inhibition
    • HOMOLOGY
    interspecies ortholog to rattus Ccng2
    ortholog to murine Ccng2
    Homologene
    FAMILY
  • cyclin family
  • cyclin G subfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • resides primarily on the mother centriole
    • basic FUNCTION
  • may play a role in growth regulation and in negative regulation of cell cycle progesssion
  • may modulate the cell cycle and cellular division processes through modulation of PP2A and centrosomal associated activities
  • critical roles of upregulation of HDAC2 and suppression of CCNG2 in Myc-induced oncogenesis
  • unconventional cyclin homolog, cyclin G2 (CycG2), linked to growth inhibition
  • contributes to DNA damage-induced G(2)/M checkpoint by enforcing checkpoint inhibition of CCNB1-CDC2 complexes
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with protein phosphatase 2A catalytic and regulatory B subunits in active complexes and induces nuclear aberrations and a G(1)/S-phase cell cycle arrest
  • NODAL suppress cell proliferation and to stimulate the expression of cyclin G2 (CCNG2) in epithelial ovarian cancer cells
  • FOXA1, but not ESR1, is essential for AHR-dependent regulation of CCNG2, assigning a role for FOXA1 in AHR action
  • AHR target gene
    • cell & other
    REGULATION
    activated by actinomycin-D induced DNA damage
    during cell cycle arrest responses to anti-proliferative signals
    repressed by by mitogens
    Other FOXA1, but not ESR1, is essential for AHR-dependent regulation of CCNG2, assigning a role for FOXA1 in AHR action
    degraded by the ubiquitin-proteasome pathway and SKP2 plays a role in regulating CCNG2 levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    its dysregulation may play an important role in epithelial transformation and the early stages of human oral cancer development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS