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FLASH GENE

Symbol

CCNE2

contributors: mct - updated : 10-11-2015

HGNC name	cyclin E2
HGNC id	1590

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q22.1      Physical location : 95.892.455 - 95.907.482
Synonym name	G1/S-specific cyclin E2
Synonym symbol(s)	CYCE2

DNA

TYPE	functioning gene
STRUCTURE	16.43 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_057749 12 - 2739 NP_477097 - 404 - 1999 9858585 variant 2 / cyclin E2(SV) - splicing 2613 - 359 - 1999 9858585 missing 45 amino acids within the cyclin box domain no binding to CDK2 translation in-frame compared to isoform 1 variant 3 - splicing 2536 34 296 - 1999 9858585 lacking an internal fragment within the coding region leading to a translation frame shift compared to variant 1 truncated protein lacking 112 N-terminal residues and having a distinct 4 aa at the N-terminus compared to isoform 1, resulting from a translation beginning at a downstream start codon in a different frame

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately Lymphoid/Immune lymph node       highly Nervous brain       moderately Reproductive female system uterus cervix   moderately   female system ovary     moderately   male system testis     highly Urinary bladder       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

cell cycle

cell cycle, checkpoint, G1S

Text	peaking at the G1/S transition

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

mono polymer

heteromer , complex

HOMOLOGY

interspecies

ortholog to murine Ccne2

Homologene

FAMILY	cyclin family
	cyclin E subfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
text	in cancer cells, unlike normal cells, the closely related protein cyclin E2 is expressed predominantly in S phase, concurrent with DNA replication

basic FUNCTION	playing an essential role in the control of the cell cycle at the late G1 and early S phase (cell cycle G1/S transition)
	involved in the regulation of cyclin dependent protein kinase
	involved in the regulation of progression through cell cycle
	activating both CDK2 and CDK3
	ectopic expression of CCNE1 enhances the ubiquitin-dependent proteolysis of CCNE2, suggesting a potential cross-talk in the regulation of E-type cyclin activity
	role of E2F1-CCNE1-CCNE2 circuit in coronary smooth muscle cell proliferation
	key role for CCNE1, CCNE2 in promoting megakaryocyte entry into S phase and hence, increase in the number of cell cycling cells and in augmenting polyploidization
	role for CCNE1, CCNE2 in the development and function of the mammalian central nervous system and its subcellular localization in neurons is important
	CCNE2 induction of genomic instability by a mechanism distinct from CCNE1 indicates that these two proteins have unique functions in a cancer setting
	CCNE1, CCNE2 control chromosome pairing, telomere stability and CDK2 localization in male meiosis

CELLULAR PROCESS	cell cycle, division
	cell cycle, checkpoint

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex
	regulatory subunit of CDK2

INTERACTION

DNA

RNA

small molecule

protein	CDK2
	CDKN1A
	ORC3L
	CIP/KIP family of CDK inhibitors
	CCNE2-CDK2 activation by estrogen occurs via E2F- and CHD8-mediated transcription of CCNE2 downstream of CCND1
	direct link between CCNE1, CCNE2 and HIF1A activities in mammary epithelial cells, implicating HIF1A is a mediator of proliferation-independent phenotypes associated with high CCNE1, CCNE2 expression in some human breast cancers

cell & other

REGULATION

activated by

papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively

Other

phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS