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FLASH GENE
Symbol CCNB3 contributors: mct - updated : 04-11-2013
HGNC name cyclin B3
HGNC id 18709
Location Xp11.23      Physical location : 50.027.539 - 50.094.909
Synonym name G2/mitotic-specific cyclin-B3
Synonym symbol(s) CYCB3
DNA
TYPE functioning gene
STRUCTURE 67.37 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
VDAC1LP Xp11.2 voltage-dependent anion channel 1-like pseudogene LOC139163 Xp11.23 similar to Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1) GAGEB1 Xp11.23 G antigen, family B, 1 (prostate associated) GAGEC1 Xp11.23 G antigen, family C, 1 LOC389856 X similar to ubiquitin specific protease 27, X chromosome CLCN5 Xp11.22 chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease) AKAP4 Xp11.2 a kinase (PRKA) anchor protein 4 CCNB3 Xp11 cyclin B3 LOC139189 Xp11.23 similar to Diacylglycerol kinase, delta (Diglyceride kinase) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase) KIAA1202 Xp11.23 similar to Diacylglycerol kinase, delta (Diglyceride kinase) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase)
RNA
TRANSCRIPTS type messenger
text three variants in the 5' UTR
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 splicing 4524 157.9 1395 - 2002 1184642
CCNB3 variant 3
8 splicing 1212 33.3 291 - 2002 1184642
  • CCNB3 variant 1
  • lacking a large internal coding region of 1104 AA than isoform 3 but remaining in frame
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Reproductivemale systemtestis  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, G1, S, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    unusually large for a mitotic cyclin
    HOMOLOGY
    interspecies homolog to C.elegans K07H8.3
    homolog to Drosophila CG11989
    Homologene
    FAMILY
  • cyclin family
  • cyclin AB subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulator of CDK kinases
  • required for proper spindle reorganisation and restoration of the interphase nucleus
  • having a dominant-negative function in competition with activating cyclins in G(0) and the G(1) phase of the cell cycle
  • downregulation of cyclin B3 at the zygotene-pachytene transition is potentially required to ensure normal spermatogenesis
  • APC and CCNB3 are potentially important markers for identifying endoderm cells differentiated from human embryonic stem cells (hESCs), and they can play important roles in the differentiation of endoderm cells from hESCs or in human endoderm development for pancreas
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to CDC2 and CDK2 kinases
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with BCOR, in bone sarcomas biologically distinct from other sarcomas, particularly Ewing sarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS