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FLASH GENE
Symbol CCNB1IP1 contributors: KTN/npt - updated : 13-01-2009
HGNC name cyclin B1 interacting protein 1
HGNC id 19437
Location 14q11.2      Physical location : 20.779.529 - 20.801.457
Synonym name
  • enhancer of invasion 10
  • chromosome 14 open reading frame 18
  • Synonym symbol(s) HEI10, C14orf18
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 21.93 kb     12 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1507 31.4 277 - Toby
    6 splicing 1307 31.4 277 - Toby
    7 splicing 1681 31.4 277 - Toby
    7 splicing 1649 31.4 277 - Toby
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
     salivary gland   highly
     stomach   highly
    Endocrineadrenal gland   moderately
     thyroid   highly
    Hearing/Equilibriumear   moderately
    Nervousbrain   lowly
    Reproductivefemale systemuteruscervix moderately
    Respiratorylung   lowly
    Urinarykidney   lowly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING-type zinc finger motif in the N terminus
  • a coiled-coil domain
  • cyclin and cyclin-dependent kinase phosphorylation sites in the C terminus
  • conjugated PhosphoP , Other
    HOMOLOGY
    interspecies homolog to dog CCNB1IP1 (95.7 pc)
    homolog to chimpanzee CCNB1IP1 (99.6 pc)
    homolog to cow CCNB1IP1 (95.3 pc)
    homolog to rattus Ccnb1ip1 (89.5 pc)
    homolog to murine Ccnb1ip1 (88.8 pc)
    Homologene
    FAMILY
  • E3 ubiquitin ligase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text may associate with segregating chromosomes during metaphase and anaphase
    basic FUNCTION
  • acting as an E3 ubiquitin-protein ligase
  • modulating cyclin B levels and participating in the regulation of cell cycle progression through the G2 phase
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CCNB1 and UBE2L3
  • cell & other
    REGULATION
    Other autoubiquitinated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    fused with HMGIC t(14;12) (q11;q14) in uterine leiomyoma
    constitutional     --over  
    delayed entry into mitosis caused by overexpression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS