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FLASH GENE

Symbol

CCNB1IP1

contributors: KTN/npt - updated : 13-01-2009

HGNC name	cyclin B1 interacting protein 1
HGNC id	19437

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q11.2      Physical location : 20.779.529 - 20.801.457
Synonym name	enhancer of invasion 10
	chromosome 14 open reading frame 18
Synonym symbol(s)	HEI10, C14orf18
EC.number	6.3.2.-

DNA

TYPE	functioning gene
STRUCTURE	21.93 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 7 splicing 1507 31.4 277 - Toby variant 2 6 splicing 1307 31.4 277 - Toby variant 3 7 splicing 1681 31.4 277 - Toby variant 4 7 splicing 1649 31.4 277 - Toby

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       lowly   salivary gland       highly   stomach       highly Endocrine adrenal gland       moderately   thyroid       highly Hearing/Equilibrium ear       moderately Nervous brain       lowly Reproductive female system uterus cervix   moderately Respiratory lung       lowly Urinary kidney       lowly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Muscular       moderately

cell lineage
cell lines
fluid/secretion	highly in lymph

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RING-type zinc finger motif in the N terminus
	a coiled-coil domain
	cyclin and cyclin-dependent kinase phosphorylation sites in the C terminus

conjugated

PhosphoP , Other

HOMOLOGY

interspecies	homolog to dog CCNB1IP1 (95.7 pc)
	homolog to chimpanzee CCNB1IP1 (99.6 pc)
	homolog to cow CCNB1IP1 (95.3 pc)
	homolog to rattus Ccnb1ip1 (89.5 pc)
	homolog to murine Ccnb1ip1 (88.8 pc)

Homologene

FAMILY

E3 ubiquitin ligase family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	may associate with segregating chromosomes during metaphase and anaphase

basic FUNCTION	acting as an E3 ubiquitin-protein ligase
	modulating cyclin B levels and participating in the regulation of cell cycle progression through the G2 phase

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to CCNB1 and UBE2L3

cell & other

REGULATION

Other

autoubiquitinated

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion translocation     fused with HMGIC t(14;12) (q11;q14) in uterine leiomyoma constitutional     --over   delayed entry into mitosis caused by overexpression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS