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FLASH GENE
Symbol CCNA1 contributors: mct - updated : 11-06-2012
HGNC name cyclin A1
HGNC id 1577
Location 13q13.3      Physical location : 37.005.966 - 37.017.018
Synonym symbol(s) CGA1
DNA
TYPE functioning gene
STRUCTURE 11.05 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
IFIT1P 13q12-q13 interferon-induced protein with tetratricopeptide repeats 1, pseudogene CG018 13q12-q13 hypothetical gene CG018 PRO0297 13q12-q13 hypothetical gene CG018 LOC88523 13q12.3 CG016 CG005 APRIN 13q12.3 androgen-induced proliferation inhibitor LOC122038 13q13.1 similar to Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) (hTom22) (1C9-2) KL 13q12 klotho LOC387918 13 LOC387918 STARD13 13q12-q13 START domain containing 13 RFC3 13q12.3-q13 replication factor C (activator 1) 3, 38kDa NBEA 13q13 neurobeachin MAB21L1 13q13.1-q13.2 mab-21-like 1 (C. elegans) DCAMKL1 13q12.3-q13 doublecortin and CaM kinase-like 1 FLJ20449 13q13.2 hypothetical protein FLJ20449 LOC387919 13 similar to RIKEN cDNA A730037C10 gene SPG20 13q13.1 spastic paraplegia 20, spartin (Troyer syndrome) LOC387920 13 similar to bA251J8.3.1 (novel protein, isoform 1) CCNA1 13q12.3-q13 cyclin A1 LOC390393 13 similar to glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)  (EC 1.2.1.12) - mouse RFXAP 13q14 regulatory factor X-associated protein MADH9 13q12-q14 MAD, mothers against decapentaplegic homolog 9 (Drosophila) LOC390394 13 similar to eukaryotic translation initiation factor 4A1; initiation factor eIF-4A long form ALG5 13q13.2 asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase) OIP2 13q13.1 Opa-interacting protein 2 P38IP 13q13.2 transcription factor (p38 interacting protein) MGC33182 13q13.2 casein kinase I alpha S-like OSF-2 TRPC4 13q13.1-q13.2 transient receptor potential cation channel, subfamily C, member 4 LOC390395 13 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) BM-002 13q13.3 hypothetical protein BM-002 DKFZp686J0811 13q13.3 hypothetical protein DKFZp686J0811 LOC390396 13 similar to KIAA1074 protein STOML3 13q13.2 stomatin (EPB72)-like 3 FLJ12661 13q13.3 hypothetical protein FLJ12661 LOC387921 13 similar to RIKEN cDNA 8030451K01 LOC390397 13 similar to NTF2-related export protein 1 (p15 protein) LHFP 13q12 lipoma HMGIC fusion partner COG6 13q13.3 component of oligomeric golgi complex 6
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1962 52 464 - 1999 10196209
9 - 1965 52.2 465 - 1999 10196209
9 - 1844 47.4 421 - 1999 10196209
9 - 1841 47.4 421 - 1999 10196209
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Nervousbrain   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines in several leukemic cell lines
fluid/secretion
at STAGE
physiological period
Text meiotic cell in the testis and brain
life cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Ccna1
intraspecies homolog to ccna2
Homologene
FAMILY
  • cyclin family
  • cyclin AB subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    text CCNA1/CDK2 localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase
    basic FUNCTION
  • regulator of cell-cycle
  • G2 phase CCNA1/CDK2 controls the timing of entry into mitosis by controlling the subsequent activation of CCNB/CDK1, but also has an unexpected role in coordinating the activation of CCNB/CDK1 at the centrosome and in the nucleus
  • cell cycle regulator that has been implicated in the progression of prostate cancer
  • having a meiosis-specific function
  • cell cycle regulator CCNA1 in association with FLT1, is required for haematopoietic stem/progenitor cells (HSPC) and their niches to maintain their function and proper interaction
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS reproduction/sex
    text regulation of spermatogenesis ; cell cycle contrôle
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with CDK2 and CDC2 protein kinases to form a serine /threonine kinase noloenzyme complex
  • contributes to prostate cancer invasion by modulating the expression of MMPs and VEGF and by interacting with AR
  • stabilized via post-transcriptional modification in response to apoptosis induced by staurosporine or TNF
  • CARM1 represses replicative senescence by methylating ELAVL1 and thereby enhancing ELAVL1 ability to regulate the turnover of CCNA1, CCNB1, FOS, SIRT1, and CDKN2A mRNAs (
  • cell & other
    REGULATION
    inhibited by RUNX1, that may negatively regulate cyclin A1 expression in hematopoietic cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS