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FLASH GENE
Symbol CCM2L contributors: mct - updated : 27-03-2018
HGNC name CCM2 like scaffold protein
HGNC id 16153
Location 20q11.21      Physical location : -
Synonym name
  • hypothetical protein LOC140706
  • chromosome 20 open reading frame 160
  • cerebral cavernous malformation 2-like
  • CCM2-like
  • Synonym symbol(s) dJ310O13.5, FLJ43600, C20orf160
    DNA
    TYPE functioning gene
    STRUCTURE 21.80 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2532 46.6 433 - 2012 22898778
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to CCM2
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • is a molecular mechanism by which endothelial cells coordinately regulate vessel stability and growth during cardiovascular development, as well as postnatal vessel growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both CCM2L and CCM2 interfere with MAP3K3 activation and its ability to phosphorylate MAP2K5, a downstream target
  • cell & other
    REGULATION
    Other expression of CCM2L in endothelial cells is regulated by density, flow, and statins
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS