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FLASH GENE
Symbol CCL7 contributors: - updated : 29-12-2005
HGNC name chemokine (C-C motif) ligand 7
HGNC id 10634
Location 17q11.2-q12      Physical location : 32.597.239 - 32.599.255
Synonym name
  • small inducible cytokine A7 (monocyte chemotactic protein 3)
  • monocyte chemoattractant protein 3
    • Synonym symbol(s) FIC, MARC, MCP3, NC28 ,MCP-3, SCYA7
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered in IMC1@
    STRUCTURE 2.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see CCL3L1
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus   
     female systemplacenta   
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a signal peptide sequence
    secondary structure a three-stranded antiparallel beta sheet covered on one face by an alpha helix
    conjugated GlycoP
    mono polymer homomer , monomer , dimer
    HOMOLOGY
    interspecies homolog to murine Ccl7
    homolog to Drosophila eg:bacr25b3.3
    homolog to C.elegans K04c2.5
    intraspecies homolog to CCL2
    homolog to CCL8
    Homologene
    FAMILY
  • C-C subfamily of chemokines
  • intecrine beta family
    • CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • attracting monocytes and eosinophils, basophil, activated T cell and dendritic cell but not neutrophils
  • attracting macrophages furing inflammation and metastasis
  • augmenting monocyte anti-tumor activity
  • inducing the release of gelatinase B
    • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS homeostasis , immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
  • cell-cell signaling
  • calcium Ca2+ homeostasis
    • a component dimer with the so-called alpha beta sandwich structural motif
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to heparin, CCR1, CCR2 and CCR3
  • being an substate of matrix metaloproteinase 2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism CA/GA microsatellite polymorphism in the promoter-enhancer region
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS