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FLASH GENE
Symbol CCL3L1 contributors: SGE/npt - updated : 13-07-2010
HGNC name chemokine (C-C motif) ligand 3-like 1
HGNC id 10628
Location 17q12      Physical location : 34.522.267 - 34.625.730
Synonym name
  • G0/G1 switch regulatory protein 19-2
  • tonsillar lymphocyte LD78 beta protein
  • small-inducible cytokine A3-like 1
  • LD78-beta(1-70)
  • C-C motif chemokine 3 like 1
  • PAT 464.2
  • Synonym symbol(s) LD78, SCYA3L, LD78BETA, MIP-1alpha P, SCYA3L1, D17S1718, G0S19-2, 464.2, MGC12815, MGC104178, MGC182017, MIP1AP, CCL3L3
    DNA
    TYPE like-sequence
    SPECIAL FEATURE component of a cluster, head to head, opposite orientation
    text
  • clustered with other C-C cytokines in IMC1@
  • head to head oritentation with SCYA4L
  • STRUCTURE 1.89 kb     3 Exon(s)    1-6 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    motif repetitive sequence   ALU
    text structure
  • a NF chi B binding site
  • a 5'Alu sequence
  • in 5' flanking sequence,CK-2 and SRE motifs
  • MAPPING cloned Y linked N status confirmed
    Map cen - NF1 NF1 - (CCL7 ,CCL2 ,CCL13 ) - Y1741 breakpoint - CCL5 - (CCL3L2 ,CCL4L1 ) - CCL18 - CCL3 - CCL4 - CCL3L1 - CCL4L1 - (CCL15 ,CCL14 )- CCL16 - RARA RARA - qter
    Authors Naruse 96, Modi (2004)
    Physical map
    VTS58635 GAR17 17q21.1 GAS2-related protein LOC146853 17q21.1 LOC146853 MMP28 17q11-q21.1 matrix metalloproteinase 28 TAF15 17q11.1-q11.2 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa FLJ32830 17q21.1 hypothetical protein FLJ32830 CCL5 17q11.2 chemokine (C-C motif) ligand 5 LOC390786 17 hypothetical gene supported by AL833376 LOC390787 17 similar to KIAA0563 protein RAD52B 17q11.2 RAD52B LOC57151 17q11.2 lysozyme homolog CCL16 17q11.2 chemokine (C-C motif) ligand 16 CCL14 17q11.2 chemokine (C-C motif) ligand 14 CCL14-CCL15 17q21.1 chemokine ligand 14, chemokine ligand 15 transcription unit CCL15 17q11.2 chemokine (C-C motif) ligand 15 CCL23 17q11.2 chemokine (C-C motif) ligand 23 CCL18 17q11.2 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) CCL3 17q11.2 chemokine (C-C motif) ligand 3 CCL4 17q11.2 chemokine (C-C motif) ligand 4 LOC388368 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388369 17 LOC388369 LOC388370 17 similar to cytokine LOC388371 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC390788 17 similar to CCL3L1 protein CCL3L1 17q11.2 chemokine (C-C motif) ligand 3-like 1 LOC388372 17 similar to cytokine LOC388373 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388374 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) TRIP3 17q21.1 thyroid hormone receptor interactor 3 FLJ22865 17q21.1 hypothetical protein FLJ22865 PIGW 17q21.1 phosphatidylinositol glycan, class W LZK1 17q21.1 C3HC4-type zinc finger protein MGC4172 17q21.1 hypothetical protein MGC4172 FLJ22578 17q21.1 hypothetical protein FLJ22578
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 804 - 93 - Nakao (1990)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils    
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Ccl3 (76.1pc)
    homolog to rattus Ccl3 (77.2pc)
    intraspecies homolog to SCYA3L2
    paralog to CCL3
    Homologene
    FAMILY
  • intercrine beta (chemokine CC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • attracting and activating leukocytes
  • having an anti-HIV-1 activity (binding to CCR5 inhibits HIV entry)
  • should be a potential chemokine to protect against neuronal injury in HIV-1 gp120-related neuronal toxicity (Chun 2009)
  • increased CCL3L1 expression may enhance inflammatory responses and increase the chance of autoimmune disease (McKinney 2008)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling, G protein linked receptor signaling pathway
    a component
  • precursor cleaved into two chains LD78-beta (3-70) and LD78-beta (5-70) by proteolytic cleavage after secretion, probably by DPP4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CCR3 and CCR5 receptor
  • binding to several chemokine receptors including chemokine binding protein 2
  • ligand for CCR1
  • cell & other
    REGULATION
    Other LPS stimulation of peripheral blood mononuclear cells increased CCL3L1 expression (Townson 2002)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to HIV/acquired immunodeficiency syndrome (AIDS)
    Variant & Polymorphism other
  • a low copy number is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility
  • lower CCL3L1 gene copy number compared to the population median is associated with chronic hepatitis C (Grünhage 2010)
  • CCR5-59029 AG genotype and CCL3L1 gene dose appear to have synergistic or interactive effects and are expected to be involved in the host innate resistance to HIV-1 infection (Rathore 2009)
  • copy number of CCL3L1 influences risk of systemic lupus erythaematosus (SLE) and modifies the SLE-influencing effects associated with the CCR5 genotypes (Mamtani 2008)
  • Candidate gene
    Marker
    Therapy target
  • CCL3L1-CCR5 variations may be useful in identifying patients requireng earlier initiation of highly active antiretroviral therapy (Ahuja 2008)
  • ANIMAL & CELL MODELS