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FLASH GENE
Symbol CCL3 contributors: mct - updated : 19-10-2010
HGNC name chemokine (C-C motif) ligand 3
HGNC id 10627
Location 17q12      Physical location : 34.415.604 - 34.417.506
Synonym name
  • murine macrophage inflammatory protein 1 alpha
  • small inducible cytokine A3 (homologous to mouse Mip-1a)
  • G0/G1 switch regulatory protein 19.1
  • monokine
  • LD78 alpha beta
  • tonsillar lymphocyte LD78 alpha protein
  • PAT 464.1
  • macrophage inflammatory protein 1-alpha
  • Synonym symbol(s) MIP1A, LD78ALPHA, MIP-1-alpha, SCYA3, G0S19-1, SIS-beta
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, head to head, opposite orientation
    text separated by 14kb from CCL4 in a head to head orientation clustered in IMC1@
    STRUCTURE 1.91 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • a binding site for NF chi B
  • 5' AP1-like recognition elements
  • CK2 and SRE motifs in 5' flanking sequence
  • MAPPING cloned Y linked N status confirmed
    Map see CCL3L1
    Physical map
    FLJ31952 17q21.1 hypothetical protein FLJ31952 LOC342615 17q21.1 similar to Adenylosuccinate synthetase 2 (IMP--aspartate ligase 2) (AdSS 2) (AMPSase 2) LOC342616 17q21.1 similar to TAF5L protein LOC342618 17q21.1 similar to FLJ34922 protein PEX12 17q21.1 peroxisomal biogenesis factor 12 AP2B1 17q11.2-q12 adaptor-related protein complex 2, beta 1 subunit VTS58635 GAR17 17q21.1 GAS2-related protein LOC146853 17q21.1 LOC146853 MMP28 17q11-q21.1 matrix metalloproteinase 28 TAF15 17q11.1-q11.2 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa FLJ32830 17q21.1 hypothetical protein FLJ32830 CCL5 17q11.2 chemokine (C-C motif) ligand 5 LOC390786 17 hypothetical gene supported by AL833376 LOC390787 17 similar to KIAA0563 protein RAD52B 17q11.2 RAD52B LOC57151 17q11.2 lysozyme homolog CCL16 17q11.2 chemokine (C-C motif) ligand 16 CCL14 17q11.2 chemokine (C-C motif) ligand 14 CCL14-CCL15 17q21.1 chemokine ligand 14, chemokine ligand 15 transcription unit CCL15 17q11.2 chemokine (C-C motif) ligand 15 CCL23 17q11.2 chemokine (C-C motif) ligand 23 CCL18 17q11.2 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) CCL3 17q11.2 chemokine (C-C motif) ligand 3 CCL4 17q11.2 chemokine (C-C motif) ligand 4 LOC388368 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388369 17 LOC388369 LOC388370 17 similar to cytokine LOC388371 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC390788 17 similar to CCL3L1 protein CCL3L1 17q11.2 chemokine (C-C motif) ligand 3-like 1 LOC388372 17 similar to cytokine LOC388373 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388374 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) TRIP3 17q21.1 thyroid hormone receptor interactor 3 FLJ22865 17q21.1 hypothetical protein FLJ22865 PIGW 17q21.1 phosphatidylinositol glycan, class W LZK1 17q21.1 C3HC4-type zinc finger protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 813 - 92 - 1992 1296815
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    isoforms Precursor a predicted mature peptide of 69 AA with a molecular mass of 7.9 kDa
    HOMOLOGY
    interspecies homolog to murine CCL3 (see IMC1@)
    homolog to Drosophila eg:bacr25b3.3
    homolog to C.elegans C06e4.2
    intraspecies paralog to CCL3L1
    Homologene
    FAMILY
  • intercrine beta (chemokine CC) family
  • CATEGORY tumor suppressor , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • monocyte, chemoattractant, activated T cell and dendritic cell
  • involved in cytoskeletal regulation
  • one of the major HIV-suppressive factors produced by CD8+ T cells
  • playing a role as an important mediator of virus-induced inflammation
  • playing a role in eosinophil recruitment in inflammatory states such as occurs in the asthmatic lung
  • inhibiting stem cell proliferation
  • contributing to intracellular signaling and other chemokine receptor function
  • CCL3/CCR1 axis may have a role in the spread of tumoral cells to the lymph nodes and also in the local host defense against the tumor
  • with CCL4, may directly or indirectly affect neuronal excitability, and are implicated in the etiology and pathogenesis of temporal lobe epilepsy
  • its expression not only reduces viral pathogenicity but also enhances immunogenicity by recruiting dendritic cells and B cells to the site of immunization, the lymph nodes, and the blood
  • for CCL3 activation of migration, no release of intracellular calcium is necessary
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text calcium Ca2+ homeostasis
    PATHWAY
    metabolism
    signaling signal transduction
  • cell-cell signaling
  • G protein linked receptor protein signaling pathway
  • a component
  • M/P1A/M/P1B heterodimer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to receptors CCR1, CCR4
  • natural ligand for the primary human immunodeficiency virus type 1 (HIV-1) coreceptor CCR5
  • interaction between ZFP36 and CCL3 mRNA plays an important role in modulating localized inflammatory processes in tissues that are dissociated from the systemic manifestations of chronic inflammation
  • CCL3 induced cell migration is dependent on activation of phospholipase C
  • cell & other
    REGULATION
    induced by LPS (lipopolysaccharides)
    inhibited by EBV (Epstein-Barr virus)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to multiple sclerosis
  • to HIV/acquired immunodeficiency syndrome (AIDS) (Omim: 609423)
  • Variant & Polymorphism SNP
  • increasing the risk of multiple sclerosis
  • influencing HIV Type 1 transmission and AIDS disease progression
  • Candidate gene
    Marker
  • autoantibody against CCL3 is associated with human type 1 diabetes mellitus (T1DM) and serves as a novel biomarker for its diagnosis
  • specifically predicts future cardiovascular events, and may serve as a predictive biomarker
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 1 
    preferential target for therapy of T1DM
    ANIMAL & CELL MODELS
    homozygous knockout mice