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Symbol CCL3 contributors: mct - updated : 19-10-2010
HGNC name chemokine (C-C motif) ligand 3
HGNC id 10627
Location 17q12      Physical location : 34.415.604 - 34.417.506
Synonym name
  • murine macrophage inflammatory protein 1 alpha
  • small inducible cytokine A3 (homologous to mouse Mip-1a)
  • G0/G1 switch regulatory protein 19.1
  • monokine
  • LD78 alpha beta
  • tonsillar lymphocyte LD78 alpha protein
  • PAT 464.1
  • macrophage inflammatory protein 1-alpha
  • Synonym symbol(s) MIP1A, LD78ALPHA, MIP-1-alpha, SCYA3, G0S19-1, SIS-beta
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, head to head, opposite orientation
    text separated by 14kb from CCL4 in a head to head orientation clustered in IMC1@
    STRUCTURE 1.91 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • a binding site for NF chi B
  • 5' AP1-like recognition elements
  • CK2 and SRE motifs in 5' flanking sequence
  • MAPPING cloned Y linked N status confirmed
    Map see CCL3L1
    Physical map
    FLJ31952 17q21.1 hypothetical protein FLJ31952 LOC342615 17q21.1 similar to Adenylosuccinate synthetase 2 (IMP--aspartate ligase 2) (AdSS 2) (AMPSase 2) LOC342616 17q21.1 similar to TAF5L protein LOC342618 17q21.1 similar to FLJ34922 protein PEX12 17q21.1 peroxisomal biogenesis factor 12 AP2B1 17q11.2-q12 adaptor-related protein complex 2, beta 1 subunit VTS58635 GAR17 17q21.1 GAS2-related protein LOC146853 17q21.1 LOC146853 MMP28 17q11-q21.1 matrix metalloproteinase 28 TAF15 17q11.1-q11.2 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa FLJ32830 17q21.1 hypothetical protein FLJ32830 CCL5 17q11.2 chemokine (C-C motif) ligand 5 LOC390786 17 hypothetical gene supported by AL833376 LOC390787 17 similar to KIAA0563 protein RAD52B 17q11.2 RAD52B LOC57151 17q11.2 lysozyme homolog CCL16 17q11.2 chemokine (C-C motif) ligand 16 CCL14 17q11.2 chemokine (C-C motif) ligand 14 CCL14-CCL15 17q21.1 chemokine ligand 14, chemokine ligand 15 transcription unit CCL15 17q11.2 chemokine (C-C motif) ligand 15 CCL23 17q11.2 chemokine (C-C motif) ligand 23 CCL18 17q11.2 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) CCL3 17q11.2 chemokine (C-C motif) ligand 3 CCL4 17q11.2 chemokine (C-C motif) ligand 4 LOC388368 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388369 17 LOC388369 LOC388370 17 similar to cytokine LOC388371 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC390788 17 similar to CCL3L1 protein CCL3L1 17q11.2 chemokine (C-C motif) ligand 3-like 1 LOC388372 17 similar to cytokine LOC388373 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388374 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) TRIP3 17q21.1 thyroid hormone receptor interactor 3 FLJ22865 17q21.1 hypothetical protein FLJ22865 PIGW 17q21.1 phosphatidylinositol glycan, class W LZK1 17q21.1 C3HC4-type zinc finger protein
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 813 - 92 - 1992 1296815
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    at STAGE
    mono polymer heteromer , dimer
    isoforms Precursor a predicted mature peptide of 69 AA with a molecular mass of 7.9 kDa
    interspecies homolog to murine CCL3 (see IMC1@)
    homolog to Drosophila eg:bacr25b3.3
    homolog to C.elegans C06e4.2
    intraspecies paralog to CCL3L1
  • intercrine beta (chemokine CC) family
  • CATEGORY tumor suppressor , signaling cytokine
    text secreted
    basic FUNCTION
  • monocyte, chemoattractant, activated T cell and dendritic cell
  • involved in cytoskeletal regulation
  • one of the major HIV-suppressive factors produced by CD8+ T cells
  • playing a role as an important mediator of virus-induced inflammation
  • playing a role in eosinophil recruitment in inflammatory states such as occurs in the asthmatic lung
  • inhibiting stem cell proliferation
  • contributing to intracellular signaling and other chemokine receptor function
  • CCL3/CCR1 axis may have a role in the spread of tumoral cells to the lymph nodes and also in the local host defense against the tumor
  • with CCL4, may directly or indirectly affect neuronal excitability, and are implicated in the etiology and pathogenesis of temporal lobe epilepsy
  • its expression not only reduces viral pathogenicity but also enhances immunogenicity by recruiting dendritic cells and B cells to the site of immunization, the lymph nodes, and the blood
  • for CCL3 activation of migration, no release of intracellular calcium is necessary
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text calcium Ca2+ homeostasis
    signaling signal transduction
  • cell-cell signaling
  • G protein linked receptor protein signaling pathway
  • a component
  • M/P1A/M/P1B heterodimer
    small molecule
  • binding to receptors CCR1, CCR4
  • natural ligand for the primary human immunodeficiency virus type 1 (HIV-1) coreceptor CCR5
  • interaction between ZFP36 and CCL3 mRNA plays an important role in modulating localized inflammatory processes in tissues that are dissociated from the systemic manifestations of chronic inflammation
  • CCL3 induced cell migration is dependent on activation of phospholipase C
  • cell & other
    induced by LPS (lipopolysaccharides)
    inhibited by EBV (Epstein-Barr virus)
    corresponding disease(s)
  • to multiple sclerosis
  • to HIV/acquired immunodeficiency syndrome (AIDS) (Omim: 609423)
  • Variant & Polymorphism SNP
  • increasing the risk of multiple sclerosis
  • influencing HIV Type 1 transmission and AIDS disease progression
  • Candidate gene
  • autoantibody against CCL3 is associated with human type 1 diabetes mellitus (T1DM) and serves as a novel biomarker for its diagnosis
  • specifically predicts future cardiovascular events, and may serve as a predictive biomarker
  • Therapy target
    diabetetype 1 
    preferential target for therapy of T1DM
    homozygous knockout mice