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FLASH GENE
Symbol CCL27 contributors: mct/npt - updated : 13-01-2010
HGNC name chemokine (C-C motif) ligand 27
HGNC id 10626
Location 9p13.3      Physical location : 34.661.892 - 34.662.689
Synonym name
  • eskine
  • skinkine
  • cutaneous T cell attracting chemokine
  • small inducible cytokine subfamily A (Cys-Cys), member 27
  • IL11R alpha locus chemokine
  • CC chemokine ILC
  • Synonym symbol(s) CTACK, ILC, ALP, SCYA27, CTAK, PESKY, skinkine, ESkine
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with CCL19 and CCL21
    STRUCTURE 0.80 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located next to IL-11 receptor alpha (IL11RA)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 469 12.6 112 - Ishikawa-Mochizuki, Morales (1999)
    - - 800 - - brain,thymus,placenta lowly Ishikawa-Mochizuki (1999)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Endocrineneuroendocrinepituitary   
    Reproductivemale systemtestis   
    Respiratorylung    
    Skin/Tegumentskin   predominantly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES basic ,globular
    STRUCTURE
    motifs/domains
  • twenty four AA signal peptide
  • HOMOLOGY
    interspecies ortholog to murine Scya27
    homolog to Drosophila eg:bacr25b3.3
    homolog to C.elegans K04C2.5
    Homologene
    FAMILY
  • intercrine beta family (CC chemokine)
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • mediating homing of lymphocytes to cutaneous sites, and playing a role in T cell-mediated skin inflammation
  • selectively attracts a tissue-specific subpopulation of memory lymphocytes (Morales 1999)
  • plays a critical role in the organization of skin-associated immune responses by regulating T cell homing under homeostatic and inflammatory conditions (Pivarcsi 2007)
  • promotes migration of cutaneous lymphocyte-associated antigen-positive lymphocytes into the skin (Campanati 2007)
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text immunoregulatory and inflammatory processes
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to receptor CCR10/GPR2 for skin homeostasis and the initiation of skin inflammation
  • interacts with SELPLG
  • ligand of CCR10
  • cell & other
    REGULATION
    activated by activated and upregulated by IL1B,TNF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in skin lesions of atopic dermatitis, contact dermatitis and psoriasis
    tumoral       gain of function
    led to decreased leukocyte recruitment to cutaneous tumor sites and significantly enhanced primary tumor growth (Pivarcsi 2007)
    constitutional     --low  
    in cutaneous expression during administration of etanercept in psoriasis could be considered a favourable prognostic marker (Campanati 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS