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FLASH GENE
Symbol CCL23 contributors: mct - updated : 14-11-2007
HGNC name chemokine (C-C motif) ligand 23
HGNC id 10622
Location 17q11.2      Physical location : 34.340.096 - 34.345.005
Synonym name
  • myeloid progenitor inhibitory factor 1
  • CK-beta 8
  • small inducible cytokine subfamily A (Cys-Cys), member 23
  • C6 beta-chemokine
  • macrophage inflammatory protein 3
  • Synonym symbol(s) CKb8, MIP3, MPIF-1, SCYA23, Ckb-8, Ckb-8-1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with SCYA15, SCYA14 and SCYA16
    STRUCTURE 5.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure NFAT, NFKB, AP-1 binding sites ( NFAT is important for maximal activation of CCL23 gene) (Shin 2007)
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ10260 17q21.1 hypothetical protein FLJ10260 FLJ31952 17q21.1 hypothetical protein FLJ31952 LOC342615 17q21.1 similar to Adenylosuccinate synthetase 2 (IMP--aspartate ligase 2) (AdSS 2) (AMPSase 2) LOC342616 17q21.1 similar to TAF5L protein LOC342618 17q21.1 similar to FLJ34922 protein PEX12 17q21.1 peroxisomal biogenesis factor 12 AP2B1 17q11.2-q12 adaptor-related protein complex 2, beta 1 subunit VTS58635 GAR17 17q21.1 GAS2-related protein LOC146853 17q21.1 LOC146853 MMP28 17q11-q21.1 matrix metalloproteinase 28 TAF15 17q11.1-q11.2 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa FLJ32830 17q21.1 hypothetical protein FLJ32830 CCL5 17q11.2 chemokine (C-C motif) ligand 5 LOC390786 17 hypothetical gene supported by AL833376 LOC390787 17 similar to KIAA0563 protein RAD52B 17q11.2 RAD52B LOC57151 17q11.2 lysozyme homolog CCL16 17q11.2 chemokine (C-C motif) ligand 16 CCL14 17q11.2 chemokine (C-C motif) ligand 14 CCL14-CCL15 17q21.1 chemokine ligand 14, chemokine ligand 15 transcription unit CCL15 17q11.2 chemokine (C-C motif) ligand 15 CCL23 17q11.2 chemokine (C-C motif) ligand 23 CCL18 17q11.2 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) CCL3 17q11.2 chemokine (C-C motif) ligand 3 CCL4 17q11.2 chemokine (C-C motif) ligand 4 LOC388368 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388369 17 LOC388369 LOC388370 17 similar to cytokine LOC388371 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC390788 17 similar to CCL3L1 protein CCL3L1 17q11.2 chemokine (C-C motif) ligand 3-like 1 LOC388372 17 similar to cytokine LOC388373 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 603 13.4 120 - Patel, Miao (2007)
    - splicing 640 - 137 very low abundancy Kwon unpublished, Miao (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text moderatly in liver and placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • containing four cysteines conserved among the CC family
  • a 21 amino-acid N terminal signal peptide
  • HOMOLOGY
    interspecies homolog to Drosophila Eg : Bacr25b3.3
    homolog to C.elegans K04c2.5
    Homologene
    FAMILY
  • small inducible cytokine, chemokine beta, CC subfamily
  • intercrine beta-family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • chemotatic activity for monocytes, resting T-lymphocytes and neutrophils
  • inhibiting proliferation of myeloid progenitor
  • cells in colony formation assays
  • chemokine that was initially characterized as a chemoattractant for monocytes and dendritic cells (Han 2009)
  • may play a direct role in angiogenesis, via the upregulation of MMP2 expression
  • promoted the chemotactic migration and differentiation of endothelial cells, and endothelial cell migration was mediated through CCR1 (Hwang 2005)
  • promoted VEGF-induced endothelial proliferation and migration, which were correlated with the maximal stimulation of KDR expression by CCL23 (Han 2009)
  • results in up-regulation of KDR receptor gene transcription and protein expression and that KDR/Flk-1 up-regulation induced by CCL23 may contribute to potentiation of VEGF action in angiogenesis (Han 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text
  • calcium ion homeostasis
  • negative control cell proliferation
  • PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • heparin, CCR1
  • enhancing the expression of MMP2 mRNA and protein levels in endothelial cells in a dose-dependent manner, but has no effect on the expression levels of MMP9, TIMP1, TIMP2, and MT1MMP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS