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FLASH GENE

Symbol

CCL22

contributors: mct/npt - updated : 28-06-2008

HGNC name	chemokine (C-C motif) ligand 22
HGNC id	10621

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q13.1      Physical location : 57.392.694 - 57.400.102
Synonym name	macrophage derived chemokine
	small inducible cytokine subfamily A (Cys-Cys), member 22
	CC chemokine STCP-1
Synonym symbol(s)	MDC, ABCD-1, SCYA22, STCP-1, DC/B-CK, MGC34554, A-152E5.1, 1-69, STCP1

DNA

TYPE	functioning gene
STRUCTURE	7.38 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 3 - 2918 10.6 93 - Mizumaki (2008)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Digestive mouth           pharynx         Lymphoid/Immune thymus         Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Scya22

Homologene

FAMILY

intercrine beta (chemokine CC) family

CATEGORY

signaling cytokine , receptor membrane

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	chemoattractant for monocytes, dendritic cells, monocyte-derived cells and natural killer cells
	may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology,and in mononuclear cell recruitment into atherosclerotic lesions and in inflammatory response
	playing an important role in the pathogenesis atopic dermatitis
	may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binds to CCR4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS