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FLASH GENE
Symbol CCL16 contributors: - updated : 01-04-2006
HGNC name chemokine (C-C motif) ligand 16
HGNC id 10614
Location 17q11.2      Physical location : 34.303.535 - 34.308.523
Genatlas name see IMC1@
Synonym name
  • new CC chemokine-like 4
  • small inducible cytokine subfamily A (Cys-Cys), member 16
    • Synonym symbol(s) LEC, LMC, NCC4, CKb12, HCC-4, LCC-1, MTN-1, SCYL4, ILINCK, SCYA16
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text with two forms generated through alternative polyadenylation sites,579 and 1503 bp,same product 120 AA (Shoudai)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Digestiveliver   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four cysteines conserved among the CC family
  • HIF1 binding site
    • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY intercrine beta family (small inducible cytokine, chemokine beta), CC subfamily
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • lymphocyte and monocyte chemoattractant
  • showing a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other upregulated by IL-10.
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS