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FLASH GENE
Symbol CCL16 contributors: - updated : 01-04-2006
HGNC name chemokine (C-C motif) ligand 16
HGNC id 10614
Location 17q11.2      Physical location : 34.303.535 - 34.308.523
Genatlas name see IMC1@
Synonym name
  • new CC chemokine-like 4
  • small inducible cytokine subfamily A (Cys-Cys), member 16
  • Synonym symbol(s) LEC, LMC, NCC4, CKb12, HCC-4, LCC-1, MTN-1, SCYL4, ILINCK, SCYA16
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ10260 17q21.1 hypothetical protein FLJ10260 FLJ31952 17q21.1 hypothetical protein FLJ31952 LOC342615 17q21.1 similar to Adenylosuccinate synthetase 2 (IMP--aspartate ligase 2) (AdSS 2) (AMPSase 2) LOC342616 17q21.1 similar to TAF5L protein LOC342618 17q21.1 similar to FLJ34922 protein PEX12 17q21.1 peroxisomal biogenesis factor 12 AP2B1 17q11.2-q12 adaptor-related protein complex 2, beta 1 subunit VTS58635 GAR17 17q21.1 GAS2-related protein LOC146853 17q21.1 LOC146853 MMP28 17q11-q21.1 matrix metalloproteinase 28 TAF15 17q11.1-q11.2 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa FLJ32830 17q21.1 hypothetical protein FLJ32830 CCL5 17q11.2 chemokine (C-C motif) ligand 5 LOC390786 17 hypothetical gene supported by AL833376 LOC390787 17 similar to KIAA0563 protein RAD52B 17q11.2 RAD52B LOC57151 17q11.2 lysozyme homolog CCL16 17q11.2 chemokine (C-C motif) ligand 16 CCL14 17q11.2 chemokine (C-C motif) ligand 14 CCL14-CCL15 17q21.1 chemokine ligand 14, chemokine ligand 15 transcription unit CCL15 17q11.2 chemokine (C-C motif) ligand 15 CCL23 17q11.2 chemokine (C-C motif) ligand 23 CCL18 17q11.2 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) CCL3 17q11.2 chemokine (C-C motif) ligand 3 CCL4 17q11.2 chemokine (C-C motif) ligand 4 LOC388368 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388369 17 LOC388369 LOC388370 17 similar to cytokine LOC388371 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC390788 17 similar to CCL3L1 protein CCL3L1 17q11.2 chemokine (C-C motif) ligand 3-like 1 LOC388372 17 similar to cytokine LOC388373 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein)
    RNA
    TRANSCRIPTS type messenger
    text with two forms generated through alternative polyadenylation sites,579 and 1503 bp,same product 120 AA (Shoudai)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Digestiveliver   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four cysteines conserved among the CC family
  • HIF1 binding site
  • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY intercrine beta family (small inducible cytokine, chemokine beta), CC subfamily
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • lymphocyte and monocyte chemoattractant
  • showing a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other upregulated by IL-10.
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS