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FLASH GENE
Symbol CCL11 contributors: mct - updated : 05-12-2008
HGNC name chemokine (C-C motif) ligand 11
HGNC id 10610
Location 17q21.1-q21.2      Physical location : 32.612.686 - 32.615.199
Synonym name
  • small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
  • eotaxin
  • eosinophil chemotactic protein
  • Synonym symbol(s) SCYA11, MGC22554, EOTA
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.51 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    SPACA3 17q12 sperm acrosome associated 3 ACCN1 17q11.2-q12 amiloride-sensitive cation channel 1, neuronal (degenerin) LOC339212 17q12 similar to tousled-like kinase 2; serine/threonine kinase; tousled-like kinase CCL2 17q11.2-q21.1 chemokine (C-C motif) ligand 2 CCL7 17q11.2-q12 chemokine (C-C motif) ligand 7 CCL11 17q21.1-q21.2 chemokine (C-C motif) ligand 11 CCL8 17q11.2 chemokine (C-C motif) ligand 8 CCL13 17q11.2 chemokine (C-C motif) ligand 13 CCL1 17q11.2 chemokine (C-C motif) ligand 1 LOC124842 17q12 hypothetical protein LOC124842 CCT6B 17q11.2 chaperonin containing TCP1, subunit 6B (zeta 2) MGC20398 17q21.1 hypothetical protein MGC20398 LIG3 17q11.2-q12 ligase III, DNA, ATP-dependent LOC117584 17q21.1 fring RAD51L3 17q11 RAD51-like 3 (S. cerevisiae) DKFZp434H2215 17q21.1 hypothetical protein DKFZp434H2215 FLJ10458 17q21.1 Notchless gene homolog (Drosophila) CMYA4 17q21.1 cardiomyopathy associated 4 FLJ40154 17q21.1 hypothetical protein FLJ40154 MGC19764 17q21.1 hypothetical protein MGC19764 FLJ34922 17q21.1 hypothetical protein FLJ34922 FLJ10260 17q21.1 hypothetical protein FLJ10260 FLJ31952 17q21.1 hypothetical protein FLJ31952 LOC342615 17q21.1 similar to Adenylosuccinate synthetase 2 (IMP--aspartate ligase 2) (AdSS 2) (AMPSase 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 925 - 97 - Clarke (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Reproductivefemale systemuterus   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Ccl11
    homolog to rattus scya11
    Homologene
    FAMILY intercrine beta family
    CATEGORY adhesion , signaling cytokine , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • eosinophil, basophil and dendritic cell, chemoattractant
  • putatively involved in eosinophil trafficking and other CCR3 mediated biological phenomena
  • involved in T lymphocyte
  • activation in the processus of allergy
  • ligand of CCR3
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCR2 (antagonist) and CCR5 (agonist)
  • SOCS1 and SOCS3 exhibit enhanced adhesion and reduced migration towards the chemokine CCL11
  • cell & other
    REGULATION
    induced by TNF-alpha
    interleukin-1 alpha
    interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in bullous pemphigoid
    Susceptibility to asthma, serum total IgE
    Variant & Polymorphism SNP
  • polymorphisms in eotaxin gene family associated with asthma, IgE, and eosinophil
  • a hexanucleotide repeat associated with asthma serum total IgE and plasma eotaxin
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS