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FLASH GENE
Symbol CCKBR contributors: mct/npt - updated : 20/09/2008
HGNC name cholecystokinin B receptor
HGNC id 1571
Location 11p15.4      Physical location : 6.280.965 - 6.293.355
Synonym name
  • gastrin receptor
  • colecystokinin-2 receptor
  • Synonym symbol(s) CCK-B, CCK2R, GASR, CCK-BR
    DNA
    TYPE functioning gene
    STRUCTURE 12.40 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1690 48 447 - Monstein
    exon a
    - - - 44 - - Monstein
    - - - 40 - - Monstein
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • an ITIM-like motif required for interaction with PTPN11 and the activation of the AKT pathway
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating the phosphatidylinositol cycle and intracellular Ca2+ mobilization
  • may have a role in the regulation of the circadian rhythm, the metabolism of cerebral cholesterol and in the regulation of the plasminogen system (Hansen 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral
    text modulator of anxiety, pain, inhibitor of dopamine mediator behaviors
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS