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FLASH GENE
Symbol CCKBR contributors: mct/npt - updated : 20/09/2008
HGNC name cholecystokinin B receptor
HGNC id 1571
Location 11p15.4      Physical location : 6.280.965 - 6.293.355
Synonym name
  • gastrin receptor
  • colecystokinin-2 receptor
    • Synonym symbol(s) CCK-B, CCK2R, GASR, CCK-BR
    DNA
    TYPE functioning gene
    STRUCTURE 12.40 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390074 11 similar to Olfactory receptor 52N5 LOC390075 11 similar to Olfactory receptor 52N1 LOC390076 11 similar to olfactory receptor MOR34-7 LOC390077 11 similar to Olfactory receptor 52N2 LOC390078 11 similar to Olfactory receptor 52E6 LOC390079 11 similar to Olfactory receptor 52E6 LOC390080 11 similar to olfactory receptor MOR32-1 LOC390081 11 similar to Olfactory receptor 52E4 LOC390082 11 similar to Olfactory receptor 52E5 LOC390083 11 similar to Olfactory receptor 56A6 LOC390084 11 similar to Olfactory receptor 56A4 LOC338751 11p15.4 similar to Olfactory receptor 52L1 LOC390085 11 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC120793 11p15.4 similar to Olfactory receptor 56A4 LOC120796 11p15.4 similar to Olfactory receptor 56A1 LOC390086 11 similar to Olfactory receptor 56A1 LOC390087 11 similar to Olfactory receptor 52L2 OR52X1P 11p15.3 olfactory receptor, family 52, subfamily X, member 1 pseudogene LOC196335 11p15.4 similar to Olfactory receptor 56B4 LOC390088 11 similar to seven transmembrane helix receptor LOC390089 11 hypothetical gene supported by AF359415 LOC255725 11p15.4 similar to seven transmembrane helix receptor LOC120787 11p15.4 similar to seven transmembrane helix receptor MGC34805 11p15.4 hypothetical protein MGC34805 DKFZP566M1046 11p15.4 hypothetical protein DKFZp566M1046 CNGA4 11p15.4 cyclic nucleotide gated channel alpha 4 CCKBR 11p15.4 cholecystokinin B receptor PRKCDBP 11p15.5-p15.4 protein kinase C, delta binding protein SMPD1 11p15.3 sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) APBB1 11p15.5 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) HPX 11p15.5 hemopexin TRIM3 11p15.5 tripartite motif-containing 3 ARFIP2 11p15 ADP-ribosylation factor interacting protein 2 (arfaptin 2) FXC1 11p15.2-p15.5 fracture callus 1 homolog (rat) LOC390090 11 similar to voltage-dependent anion channel 1 FLJ35709 11p15.4 hypothetical protein FLJ35709 LOC387749 11 hypothetical gene supported by BX647806 LOC196337 11p15.4 hypothetical protein LOC196337 LOC387750 11 similar to SI:zC220F6.1 (novel protein similar to human dynein heavy chain (DHC)) FLJ32752 11p15.4 hypothetical protein FLJ32752 KIAA0409 11p15.5-p15.2 hypothetical protein FLJ32752 ILK 11p15.3 integrin-linked kinase TAF10 11p15.3 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa CLN2 11p15.3 ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease) PCDH16 11p15.4 protocadherin 16 dachsous-like (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1690 48 447 - Monstein
    exon a
    - - - 44 - - Monstein
    - - - 40 - - Monstein
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • an ITIM-like motif required for interaction with PTPN11 and the activation of the AKT pathway
    • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating the phosphatidylinositol cycle and intracellular Ca2+ mobilization
  • may have a role in the regulation of the circadian rhythm, the metabolism of cerebral cholesterol and in the regulation of the plasminogen system (Hansen 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral
    text modulator of anxiety, pain, inhibitor of dopamine mediator behaviors
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS