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FLASH GENE
Symbol CCKAR contributors: - updated : 28-02-2007
HGNC name cholecystokinin A receptor
HGNC id 1570
Location 4p15.2-p15.1      Physical location : 26.483.017 - 26.492.042
Synonym name cholecystokinin-1 receptor
Synonym symbol(s) CCK-A, CCK1-R, CCKRA
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map pter - D4S1609 - D4S391 - CCKAR - D4S863 - cen
Authors Inoue (97)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • stimulating the phosphatidylinositol cycle, pancreatic enzyme secretion and dopamine-mediated behaviors
  • major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach
  • regulates satiety and the release of beta-endorphin and dopamine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral , digestion
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein CCK,GAS
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to variation of intelligence
  • to alcolholic dependence
    • Variant & Polymorphism SNP , other
  • G>T 5'utr, putatively involved in proportion of body fat content
  • promoter polymorphism increasing or decreasing the intelligence
  • 81A/G polymorphism, especially in the -81G allele, may be associated with intractable alcoholism.
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS