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FLASH GENE

Symbol

CCK

contributors: mct - updated : 03/12/2008

HGNC name	cholecystokinin
HGNC id	1569

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p22.1      Physical location : 42.299.317 - 42.307.662
Synonym symbol(s)	MGC117187

DNA

TYPE	functioning gene
STRUCTURE	8.35 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000729 5 - 1511 NP_000720 12.5 115 - 2008 18234641 NM_001174138 3 - 769 NP_001167609 - 115 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine small intestine duodenum     Nervous brain         Reproductive female system placenta         male system prostate       Visual eye

cells

System Cell Pubmed Species Stage Rna symbol Digestive epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

isoforms

Precursor

precursor processed by endo and exo-proteolytic cleavages 33AA peptide into a tetrapeptide amide sequence identical to that of gastrin

HOMOLOGY

Homologene

FAMILY

gastrin/cholecystin family

CATEGORY

signaling hormone neurotransmitter

SUBCELLULAR LOCALIZATION	extracellular
	intracellular

basic FUNCTION	involved in gallbladder contraction
	by separately regulating EGR1 activation and synthesis, CCK and leptin interact cooperatively to define the capacity for satiety signaling by vagal afferent neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

behavioral

text	regulator of feeding by producing a feeling of satiety, also involved in learning, memory, anxiety, pain, drug dependence

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	receptors CCKAR, CCKBR
	interacting with leptin and EGR1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to obesity

Variant & Polymorphism other	obese carriers of common allelic variations in CCK had an increased risk to eating increased meal sizes

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS