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FLASH GENE
Symbol CCDC94 contributors: mct - updated : 14-12-2015
HGNC name coiled-coil domain containing 94
HGNC id 25518
Location 19p13.3      Physical location : 4.247.110 - 4.269.083
Synonym symbol(s) FLJ10374
DNA
TYPE functioning gene
STRUCTURE 21.97 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
Map pter - EBI3 - CCDC94 - SHD - FSD1 - STAP2 - SH3GL1 - MLLT1 - cen
Authors Vieira (06)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1441 - 323 - 2012 22952453
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
 intestinelarge intestinerectum highly
Endocrineadrenal gland   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a FH1 (formin homology 1) domain
  • a FH2 (formin homology 2) domain
  • three predicted coiled-coil domains
  • HOMOLOGY
    Homologene
    FAMILY formin homology family, cappuccino subfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • negatively regulating cell cycle progression and proliferation
  • is a dose-dependent modifier of the anti-apoptotic function of BCL2 in a manner that is genetically upstream of BCL2 in the DSB-DDR pathway
  • new role for CCDC94 in embryonic development as a negative regulator of TP53 mRNA and protein expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCDC94 and the PRPF9 complex protect cells from IR-induced apoptosis by repressing the expression of TP53 mRNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS