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FLASH GENE
Symbol CCDC91 contributors: npt/mct - updated : 05-02-2009
HGNC name coiled-coil domain containing 91
HGNC id 24855
Location 12p11.22      Physical location : 28.410.132 - 28.703.098
Synonym name
  • GGA (Golgi-localized, gamma-ear-containing, ADP-ribosylation factor-binding proteins)- binding partner
  • p56 accessory protein
  • Synonym symbol(s) p56, FLJ11088, DKFZp779L1558, HSD8, GGABP
    DNA
    TYPE like-sequence
    STRUCTURE 293.00 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2352 50 441 - Mardones (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Urinarybladder   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an NH(2)-terminal VHS domain
  • a GAT domain
  • a variable domain
  • a gamma-adaptin ear homology domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • trans-Golgi network accessory protein that promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting (Mardones 2007)
  • cooperates with the GGAs in the sorting of cathepsin D to lysosomes, probably by enabling the movement of GGA-containing transport carriers (Mardones 2007)
  • facilitate trafficking from the trans-Golgi network to endosomes (Hirst 2001)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein bind to the appendage domains of both the AP1 gamma subunit and the GGAs (Lui 2003)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS