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FLASH GENE
Symbol CCDC88B contributors: mct - updated : 05-02-2009
HGNC name coiled-coil domain containing 88B
HGNC id 26757
Location 11q13.1      Physical location : 64.107.689 - 64.125.005
Synonym name
  • coiled-coil domain containing 88
  • brain leucine zipper protein
  • hook-related protein 3
  • 78 kDa glucose-regulated protein [GRP78]-interacting protein
  • Synonym symbol(s) CCDC88, FLJ37970, BRLZ, HKRP3, FLJ00354, DKFZp434G0920, GIPIE
    DNA
    TYPE functioning gene
    STRUCTURE 17.31 kb     27 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 4927 164.6 1476 - Simpson (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus containing a putative microtubule-binding domain that can bind microtubules in the Hook protein
  • the central region of each protein is comprised of an extensive coiled-coil domain
  • several conserved domains, including a unique C-terminal HkRP domain (Simpson 2005)
  • HOMOLOGY
    Homologene
    FAMILY
  • Hook-related protein (HkRP) family, CCDC88 family
  • Girdin family protein
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be functioning in linking organelles to microtubules*
  • having a protective role in endoplasmic reticulum stress responses in endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CCDC88B/GRP78 interaction controls the IRE1-JNK signaling pathway to protect endothelial cells against ER stress-induced apoptosis in pathological contexts such as atherosclerosis and vascular endothelial dysfunction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in endothelial cells, interacts with GRP78, a master regulator of the unfolded protein response
  • stabilizes the interaction between GRP78 and the ER stress sensor inositol-requiring protein 1 (IRE1) at the ER, leading to the attenuation of IRE1-induced c-Jun N-terminal kinase (JNK) activation
  • cell & other
    REGULATION
    induced by upon ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS