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FLASH GENE
Symbol CCDC64 contributors: shn - updated : 20-09-2010
HGNC name coiled-coil domain containing 64
HGNC id 33584
Location 12q24.23      Physical location : 120.427.647 - 120.532.299
Synonym name
  • BICD-related protein 1
  • WUGSC:H_267D11.1
  • bicaudal D-related protein 1
  • coiled-coil domain-containing protein 64A
    • Synonym symbol(s) BICDR-1, FLJ26450, H_267D11.1
    DNA
    TYPE functioning gene
    STRUCTURE 104.65 kb     9 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D12S321 - D12S1666 - CCDC64 - D12S1721 - D12S2073 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3081 73 573 highly in kidney and moderately in testis and brain PMID: 20360680
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text neuronal tissues during development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two coiled-coil region
    • conjugated
    HOMOLOGY
    interspecies ortholog to nfkb1, Danio rerio
    ortholog to Ccdc64, Mus musculus
    Homologene
    FAMILY
  • BICDR family
    • CATEGORY
    SUBCELLULAR LOCALIZATION
    text perinuclear around the a-tubulin-labelled centrosome
    basic FUNCTION
  • a key component of the molecular machinery controlling the secretory vesicle transport during the early phase of neuronal differentiation
  • controls the pericentrosomal localization of Rab6-positive secretory vesicles and the timing of neurite outgrowth
  • required for neural development and controls neuronal differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • effector of the small GTPase Rab6
  • RAB6A and RAB6B
  • kinesin family member 1C, KIF1C and the dynein/dynactin retrograde motor complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disrupted neural development and eye failed to develop in specific zebrafish morpholinos which blocks BICDR1 expression