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FLASH GENE
Symbol CCDC62 contributors: SGE - updated : 25/11/2008
HGNC name coiled-coil domain containing 62
HGNC id 30723
Location 12q24.31      Physical location : 123.259.072 - 123.311.925
Synonym name
  • testis-specific protein TSP-NY
  • Aaa-protein
  • cancer/testis antigen 109
  • coiled-coil domain-containing protein 60
  • Synonym symbol(s) TSP-NY, FLJ40344, FLJ25432, aaa, CT109, ERAP75
    DNA
    TYPE functioning gene
    STRUCTURE 52.86 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text
  • variant 2 is aberrrantly expressed in a variety of cancer, including stomach cancer, and is immunogenic in cancer patients (Domae 2009)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3107 77 682 - Domae (2009)
  • isoform a
  • 13 - 3201 77.6 684 - Domae (2009)
  • isoform b
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines PCa cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • coiled-coil domain
  • HOMOLOGY
    interspecies homolog to murine Ccdc62 (77.7pc)
    homolog to rattus Ccdc62 (78.4pc)
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • functioning as a coactivator that can modulate ER-beta transactivation and receptor function in prostate cancer cells (Chen 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ER-alpha (Chen 2008)
  • cell & other
    REGULATION
    Other ER-alpha coactivator in prostate stromal cells (Chen 2008)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS