Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCDC36 contributors: mct - updated : 12-06-2018
HGNC name coiled-coil domain containing 36
HGNC id 27945
Location 3p21.31      Physical location : 49.235.860 - 49.295.537
Synonym name
  • cancer/testis antigen 74
  • interactor of HORMAD1 protein 1
  • Synonym symbol(s) FLJ25320, CT74, IHO1
    DNA
    TYPE functioning gene
    STRUCTURE 59.68 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2696 65.1 594 - 2016 26871637
    10 - 2994 - 594 - 2016 26871637
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • coiled-coil domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • CCDC36 and conserved SPO11-auxiliary proteins MEI4 and REC114 assemble chromatin-bound recombinosomes that are predicted activators of DSB formation
  • has HORMAD1-independent DSB formation-promoting activity
  • unlike HORMAD1, is dispensable for elimination of asynaptic oocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MEI4 and CCDC36 likely remain in a complex along axes in later stages
  • MEI4, REC114 and CCDC36 are components of putative DSB-promoting recombinosomes that form on chromatin at the onset of meiosis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCDC36 as a direct interactor of HORMAD1 that is essential for DSB formation
  • HORMAD1 recruits CCDC36 to unsynapsed axes
  • if CCDC36 mediates HORMAD1 function in DSB formation, then CCDC36 loss should also affect MEI4 complex assembly
  • CCDC36 also interacted with REC114, which is a conserved binding partner of MEI4
  • CXXC1 interacts with CCDC36, an essential component of the meiotic double-strand break (DSB) machinery
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Ccdc36 -/- mice were viable without obvious somatic defects, but both sexes were infertile