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FLASH GENE
Symbol CCDC136 contributors: KTN/npt - updated : 01/10/2008
HGNC name coiled-coil domain containing 136
HGNC id 22225
Location 7q33      Physical location : 128.432.098 - 128.462.183
Synonym name nasopharyngeal carcinoma-associated gene 6 protein
Synonym symbol(s) KIAA1793, NAG6, MGC129657, MGC176632, DKFZP434G156
DNA
TYPE functioning gene
STRUCTURE 30.09 kb     18 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 4168 133.9 1154 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   moderately
Reproductivefemale systemuteruscervix moderately
 male systemtestis  predominantly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two leucine-rich repeats (LRR)
  • two coiled-coil domains
  • four protein kinase C phosphorylation sites
  • HOMOLOGY
    interspecies homolog to chimpanzee CCDC136 (96.6 pc)
    homolog to cow CCDC136 (76.7 pc)
    homolog to rattus Ccdc136 (74.3 pc)
    homolog to murine Ccdc136 (72.8 pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    text single-pass membrane protein
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    down-regulated in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS