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FLASH GENE
Symbol CCDC13 contributors: mct - updated : 31-05-2014
HGNC name coiled-coil domain containing 13
HGNC id 26358
Location 3p22.1      Physical location : 42.749.874 - 42.814.745
Synonym symbol(s) FLJ25467
DNA
TYPE functioning gene
STRUCTURE 64.98 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2847 80 715 - 2014 2481656
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • CCDC13 localises to the basal body, is required for primary cilia formation, and promotes the localisation of the ciliopathy protein BBS4 to both centriolar satellites and cilia
  • basic FUNCTION
  • is a centriolar satellite protein that functions to promote both genome stability and cilia formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCDC13 is a newly identified centriolar satellite protein that interacts with PCM1, CEP290 and pericentrin and prevents the accumulation of DNA damage during mitotic transit
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS