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FLASH GENE
Symbol CCDC106 contributors: npt - updated : 05-02-2005
HGNC name coiled-coil domain containing 106
HGNC id 30181
Location 19q13.42      Physical location : 56.158.953 - 56.164.524
Synonym name protein predicted by clone 23882
Synonym symbol(s) HSU79303, ZNF581
DNA
TYPE functioning gene
STRUCTURE 5.57 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text three transcripts differ in their second exons due to the use of different splice acceptor site, but encode an identical protein of 280 residues (Zhou 2010)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1993 32 280 - Zhou (2010)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a bipartite nuclear localization domain
  • a coiled-coil domain
  • HOMOLOGY
    interspecies homolog to murine Ccdc106 (89.6pc)
    homolog to rattus Ccdc106 (93.2pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • promoting the degradation of TP53 and inhibiting its transactivity (Zhou 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TP53 (Zhou 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS