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FLASH GENE
Symbol CCBL1 contributors: mct/npt - updated : 24-05-2008
HGNC name cysteine conjugate-beta lyase, cytoplasmic
HGNC id 1564
Location 9q34.1      Physical location : 131.595.392 - 131.644.354
Synonym name
  • glutamine transaminase K, glutamine-phenylpyruvate amino-transferase
  • kynurenine aminotransferase III
  • cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)
  • glutamine transaminase K
    • Synonym symbol(s) GTK, KAT1, KATI, FLJ95217, MGC29624
    EC.number 2.6.1.64, 2.6.1.7, 4.4.1.13
    DNA
    TYPE functioning gene
    STRUCTURE 48.90 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1925 - 422 - Lamesch (2007)
    - - 1936 - 422 - Lamesch (2007)
    - - 1792 - 372 - Lamesch (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivefemale systemuteruscervix highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • class-I pyridoxal-phosphate-dependent aminotransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • conjugating certain hologenated alkenes and alkanes
  • enzyme responsible for synthesis of kynurenic acid (KYNA), a well established neuroprotective and anticonvulsant agent, involved in synaptic transmission
  • implicated in the pathophysiology of schizophrenia, Huntington's disease and other neurological disorders
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS